Title:
EXPRESSION REGULATOR FOR GENE INVOLVED IN SKIN FUNCTION-ASSOCIATED FACTOR
Document Type and Number:
WIPO Patent Application WO/2023/181755
Kind Code:
A1
Abstract:
Provided is: a highly-safe and low-cost expression regulator for a factor particularly involved in maturation, moisture retention, or barrier function of the skin; an expression enhancer for an antimicrobial peptide; an expression enhancer for an antioxidation factor; or an expression inhibitor for a hyperpigmentation factor. This expression regulator contains an oil or fat obtained from a filamentous fungus of the genus Mortierella, and has an excellent function of regulating expression of a factor involved in maturation, moisture retention, or barrier function of the skin, an excellent function of enhancing expression of an antimicrobial peptide, an excellent function of enhancing expression of an antioxidation factor, or an excellent function of inhibiting expression of a hyperpigmentation factor.
Inventors:
SUGAHARA TOMOHIRO (JP)
YAMASHITA CHIKAKO (JP)
YAMAMOTO SHUHEI (JP)
YAMASHITA CHIKAKO (JP)
YAMAMOTO SHUHEI (JP)
Application Number:
PCT/JP2023/006209
Publication Date:
September 28, 2023
Filing Date:
February 21, 2023
Export Citation:
Assignee:
TOYO BOSEKI (JP)
International Classes:
A61K36/06; A23L31/00; A23L33/115; A23L33/135; A61K8/36; A61K8/92; A61K8/9728; A61K8/99; A61K9/06; A61K31/20; A61K31/201; A61K31/202; A61K35/74; A61P11/02; A61P11/06; A61P17/00; A61P17/02; A61P17/06; A61P17/10; A61P17/16; A61P17/18; A61P31/10; A61P37/08; A61P39/06; A61P43/00; A61Q19/00; C12N1/14; C12P7/64; C12R1/645
Domestic Patent References:
| WO2012153832A1 | 2012-11-15 |
Foreign References:
| JP2006219454A | 2006-08-24 | |||
| JP2005179211A | 2005-07-07 | |||
| JPS61130237A | 1986-06-18 | |||
| JPS6438007A | 1989-02-08 |
Other References:
HUBER KRISTEN L., FERNÁNDEZ JOSÉ R., WEBB COREY, ROUZARD KARL, HEALY JASON, TAMURA MASANORI, VORONKOV MICHAEL, STOCK JEFFRY B., ST: "HYVIA: A novel, topical chia seed extract that improves skin hydration", JOURNAL OF COSMETIC DERMATOLOGY, vol. 19, no. 9, 1 September 2020 (2020-09-01), GB , pages 2386 - 2393, XP093095671, ISSN: 1473-2130, DOI: 10.1111/jocd.13469
MELO ITAMAR S., SANTOS SUIKINAI N., ROSA LUIZ H., PARMA MARCIA M., SILVA LEONARDO J., QUEIROZ SONIA C. N., PELLIZARI VIVIAN H.: "Isolation and biological activities of an endophytic Mortierella alpina strain from the Antarctic moss Schistidium antarctici", EXTREMOPHILES, vol. 18, no. 1, 1 January 2014 (2014-01-01), Tokyo, pages 15 - 23, XP093095672, ISSN: 1431-0651, DOI: 10.1007/s00792-013-0588-7
HUANG ZE‐DIAO, WANG WEN‐JING, HAN XIAO‐LE, YANG XIAO‐LONG: "Three New Hydroxyphenylacetic Acid Derivatives and A New Alkaloid from Endophytic Fungus Mortierella sp. in Epimedium acuminatum Franch. and Their Antibacterial Activity", CHEMISTRY & BIODIVERSITY, vol. 18, no. 12, 1 December 2021 (2021-12-01), CH , pages 1 - 7, XP093095673, ISSN: 1612-1872, DOI: 10.1002/cbdv.202100741
HIROTA AKIRA, MORIMITSU YASUJIRO, HOJO HIROSHI: "New Antioxidative Indophenol-reducing Phenol Compounds Isolated from the Mortierella sp . Fungus", BIOSCIENCE, BIOTECHNOLOGY, AND BIOCHEMISTRY, vol. 61, no. 4, 1 January 1997 (1997-01-01), pages 647 - 650, XP093095674
LIN YUE-XIN: "Effects of Mortierella Isabelina Mycelia Powder on LPO, SOD and Immune Organs of Mice", JOURNAL OF FUJIAN TEACHERS UNIVERSITY ( NATURAL SCIENCE), vol. 18, no. 4, 1 December 2002 (2002-12-01), pages 69 - 72, XP093095675
WU JIAJIA, GAO BIN, ZHU SHUNYI: "The Fungal Defensin Family Enlarged", PHARMACEUTICALS, vol. 7, no. 8, pages 866 - 880, XP093095676, DOI: 10.3390/ph7080866
MELO ITAMAR S., SANTOS SUIKINAI N., ROSA LUIZ H., PARMA MARCIA M., SILVA LEONARDO J., QUEIROZ SONIA C. N., PELLIZARI VIVIAN H.: "Isolation and biological activities of an endophytic Mortierella alpina strain from the Antarctic moss Schistidium antarctici", EXTREMOPHILES, vol. 18, no. 1, 1 January 2014 (2014-01-01), Tokyo, pages 15 - 23, XP093095672, ISSN: 1431-0651, DOI: 10.1007/s00792-013-0588-7
HUANG ZE‐DIAO, WANG WEN‐JING, HAN XIAO‐LE, YANG XIAO‐LONG: "Three New Hydroxyphenylacetic Acid Derivatives and A New Alkaloid from Endophytic Fungus Mortierella sp. in Epimedium acuminatum Franch. and Their Antibacterial Activity", CHEMISTRY & BIODIVERSITY, vol. 18, no. 12, 1 December 2021 (2021-12-01), CH , pages 1 - 7, XP093095673, ISSN: 1612-1872, DOI: 10.1002/cbdv.202100741
HIROTA AKIRA, MORIMITSU YASUJIRO, HOJO HIROSHI: "New Antioxidative Indophenol-reducing Phenol Compounds Isolated from the Mortierella sp . Fungus", BIOSCIENCE, BIOTECHNOLOGY, AND BIOCHEMISTRY, vol. 61, no. 4, 1 January 1997 (1997-01-01), pages 647 - 650, XP093095674
LIN YUE-XIN: "Effects of Mortierella Isabelina Mycelia Powder on LPO, SOD and Immune Organs of Mice", JOURNAL OF FUJIAN TEACHERS UNIVERSITY ( NATURAL SCIENCE), vol. 18, no. 4, 1 December 2002 (2002-12-01), pages 69 - 72, XP093095675
WU JIAJIA, GAO BIN, ZHU SHUNYI: "The Fungal Defensin Family Enlarged", PHARMACEUTICALS, vol. 7, no. 8, pages 866 - 880, XP093095676, DOI: 10.3390/ph7080866
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