Title:
EXTRACTS FROM SPERMATOPHYTE PLANTS WITH IMMUNOMODULATING ACTIVITY
Document Type and Number:
WIPO Patent Application WO2001091764
Kind Code:
A3
Abstract:
A method is described for the extraction of products having a pharmacolmogical activity, in particular an immunomodulating activity, from spermatophyte plants. Said products, which are to be used in the pharmaceutical fields, consist of complex mixtures of compounds characterized by one or more stilbene groups, variously hydroxylated and/or glucosidated, and of compounds derived from said group by natural enzymatic biosynthetical processes (stilbenoids). The following compounds are prefered: T-Res, C-Res, glucosidated C-Res, -viniferine, H-gnetine, r-2-viniferine, r-viniferine, hopeaphenol, Ampelopepsin A and glucosidated T-Res.
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Inventors:
RAVAGNAN GIAMPIETRO (IT)
FALCHETTI ROBERTO (IT)
LANZILLI GIULIA (IT)
FUGGETTA MARIA PIA (IT)
TRICARICO MARIA (IT)
MATTIVI FULVIO (IT)
FALCHETTI ROBERTO (IT)
LANZILLI GIULIA (IT)
FUGGETTA MARIA PIA (IT)
TRICARICO MARIA (IT)
MATTIVI FULVIO (IT)
Application Number:
PCT/IB2001/000983
Publication Date:
August 15, 2002
Filing Date:
May 29, 2001
Export Citation:
Assignee:
CONSIGLIO NAZIONALE RICERCHE (IT)
ISTITUTO AGRARIO DI S MICHELE (IT)
RAVAGNAN GIAMPIETRO (IT)
FALCHETTI ROBERTO (IT)
LANZILLI GIULIA (IT)
FUGGETTA MARIA PIA (IT)
TRICARICO MARIA (IT)
MATTIVI FULVIO (IT)
ISTITUTO AGRARIO DI S MICHELE (IT)
RAVAGNAN GIAMPIETRO (IT)
FALCHETTI ROBERTO (IT)
LANZILLI GIULIA (IT)
FUGGETTA MARIA PIA (IT)
TRICARICO MARIA (IT)
MATTIVI FULVIO (IT)
International Classes:
A61K31/05; A61K31/704; A61K36/00; A61K36/18; A61K45/06; C07H1/06; C07H15/00; (IPC1-7): A61K35/78; A61K31/05; A61P37/00
Domestic Patent References:
| WO2001003713A1 | 2001-01-18 | |||
| WO1999058119A1 | 1999-11-18 | |||
| WO2001030336A2 | 2001-05-03 |
Other References:
MATTIVI FULVIO ET AL: "Isolation, characterization, and evolution in red wine vinification of resveratrol monomers.", JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, vol. 43, no. 7, 1995, pages 1820 - 1823, XP002197355, ISSN: 0021-8561
KORHAMMER SIEGFRIED ET AL: "An oligostilbene from Vitis roots.", PHYTOCHEMISTRY (OXFORD), vol. 38, no. 6, 1995, pages 1501 - 1504, XP000946048, ISSN: 0031-9422
TRELA B C ET AL: "RESVERATROL: ISOMERIC MOLAR ABSORPTIVITIES AND STABILITY", JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, AMERICAN CHEMICAL SOCIETY. WASHINGTON, US, vol. 44, no. 5, 1 May 1996 (1996-05-01), pages 1253 - 1257, XP000583846, ISSN: 0021-8561
OHYAMA MASAYOSHI ET AL: "Antitumor agents 200. Cytotoxicity of naturally occurring resveratrol oligomers and their acetate derivatives.", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 9, no. 20, 18 October 1999 (1999-10-18), pages 3057 - 3060, XP002196352, ISSN: 0960-894X
CHEONG, HO ET AL: "Anti-allergic action of resveratrol and related hydroxystilbenes", PLANTA MED. (1999), 65(3), 266-268, XP001032461
GIOVANNINI, L. ET AL: "Pretreatment with resveratrol, a natural compound from grapes and wine, decreases ischemia/reperfusion-induced polymorphonuclear cell infiltration in rat kidney", INTERNATIONAL JOURNAL OF IMMUNOTHERAPY (2000), 16(1/2), 19-26, XP001069872
KIMURA Y ET AL: "Effects of naturally occurring stilbene glucosides from medicinal plants and wine, on tumour growth and lung metastasis in Lewis lung carcinoma-bearing mice.", JOURNAL OF PHARMACY AND PHARMACOLOGY, (2000 OCT) 52 (10) 1287-95., XP001069866
GAO X ET AL: "Immunomodulatory activity of resveratrol: suppression of lymphocyte proliferation, development of cell-mediated cytotoxicity, and cytokine production.", BIOCHEMICAL PHARMACOLOGY, (2001 NOV 1) 62 (9) 1299-308., XP002197358
FALCHETTI R ET AL: "Effects of resveratrol on human immune cell function.", LIFE SCIENCES, (2001 NOV 21) 70 (1) 81-96., XP002197359
KORHAMMER SIEGFRIED ET AL: "An oligostilbene from Vitis roots.", PHYTOCHEMISTRY (OXFORD), vol. 38, no. 6, 1995, pages 1501 - 1504, XP000946048, ISSN: 0031-9422
TRELA B C ET AL: "RESVERATROL: ISOMERIC MOLAR ABSORPTIVITIES AND STABILITY", JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, AMERICAN CHEMICAL SOCIETY. WASHINGTON, US, vol. 44, no. 5, 1 May 1996 (1996-05-01), pages 1253 - 1257, XP000583846, ISSN: 0021-8561
OHYAMA MASAYOSHI ET AL: "Antitumor agents 200. Cytotoxicity of naturally occurring resveratrol oligomers and their acetate derivatives.", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 9, no. 20, 18 October 1999 (1999-10-18), pages 3057 - 3060, XP002196352, ISSN: 0960-894X
CHEONG, HO ET AL: "Anti-allergic action of resveratrol and related hydroxystilbenes", PLANTA MED. (1999), 65(3), 266-268, XP001032461
GIOVANNINI, L. ET AL: "Pretreatment with resveratrol, a natural compound from grapes and wine, decreases ischemia/reperfusion-induced polymorphonuclear cell infiltration in rat kidney", INTERNATIONAL JOURNAL OF IMMUNOTHERAPY (2000), 16(1/2), 19-26, XP001069872
KIMURA Y ET AL: "Effects of naturally occurring stilbene glucosides from medicinal plants and wine, on tumour growth and lung metastasis in Lewis lung carcinoma-bearing mice.", JOURNAL OF PHARMACY AND PHARMACOLOGY, (2000 OCT) 52 (10) 1287-95., XP001069866
GAO X ET AL: "Immunomodulatory activity of resveratrol: suppression of lymphocyte proliferation, development of cell-mediated cytotoxicity, and cytokine production.", BIOCHEMICAL PHARMACOLOGY, (2001 NOV 1) 62 (9) 1299-308., XP002197358
FALCHETTI R ET AL: "Effects of resveratrol on human immune cell function.", LIFE SCIENCES, (2001 NOV 21) 70 (1) 81-96., XP002197359
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