Title:
EYEDROPS FOR AMELIORATING OR PREVENTING RETINAL CIRCULATORY DISTURBANCE AND DISORDERS ASSOCIATED WITH RETINAL NERVE BLOOD VESSELS
Document Type and Number:
WIPO Patent Application WO/2022/107886
Kind Code:
A1
Abstract:
Eyedrops for ameliorating retinal circulatory disturbance and disorders associated with retinal nerve blood vessels, which contains fibrate-containing nanoparticles.
Inventors:
NAGAOKA TAIJI (JP)
NAGAI NORIAKI (JP)
YOKOTA HARUMASA (JP)
YAMAGAMI SATORU (JP)
HANAGURI JUNYA (JP)
OTAKE HIROKO (JP)
NAGAI NORIAKI (JP)
YOKOTA HARUMASA (JP)
YAMAGAMI SATORU (JP)
HANAGURI JUNYA (JP)
OTAKE HIROKO (JP)
Application Number:
PCT/JP2021/042628
Publication Date:
May 27, 2022
Filing Date:
November 19, 2021
Export Citation:
Assignee:
UNIV NIHON (JP)
UNIV KINKI (JP)
UNIV KINKI (JP)
International Classes:
A61K31/216; A61K9/10; A61K47/38; A61K47/40; A61P27/02
Foreign References:
| JP2016512562A | 2016-04-28 | |||
| JP2020192736A | 2020-12-03 | |||
| JP2016539098A | 2016-12-15 |
Other References:
WEI SHEN YANG GAO, GAO YANG, SHEN WEI, ZHANG QINGJIONG, HU YANG, CHEN YING, M D, PH D: "Therapeutic Potential of Topical Fenofibrate Eyedrops in Diabetic Retinopathy and AMD Rat Models", JOURNAL OF CLINICAL & EXPERIMENTAL OPHTHALMOLOGY, vol. 05, no. 04, 1 January 2014 (2014-01-01), pages 1000347 - 9, XP055932150, ISSN: 2155-9570, DOI: 10.4172/2155-9570.1000347
NAGAI NORIAKI: "Evaluation Based on Pharmaceutical Characteristics and Design of Novel Nanomedicine in the Ophthalmic Field", IRYO YAKUGAKU - JAPANESE JOURNAL OF PHARMACEUTICAL HEALTH CAREAND SCIENCES, NIHON BYOIN YAKUZAISHIKAI, TOKYO, JP, vol. 44, no. 10, 10 October 2018 (2018-10-10), JP , pages 481 - 490, XP055932154, ISSN: 1346-342X, DOI: 10.5649/jjphcs.44.481
OTAKE HIROKO, YU MANO, NORIAKI NAGAI: "Development of Nano Ophthalmic Formulation for Improving Intraocular Drug Delivery", THE JOURNAL OF THE JAPANESE SOCIETY FOR CATARACT RESEARCH, vol. 31, no. 1, 1 January 2019 (2019-01-01), pages 33 - 35, XP055932174, ISSN: 0915-4302, DOI: 10.14938/cataract.11-007
QAMAR ZUFIKA, QIZILBASH FARHEEN FATIMA, IQUBAL MOHAMMAD KASHIF, ALI ASGAR, NARANG JASJEET KAUR, ALI JAVED, BABOOTA SANJULA: "Nano-Based Drug Delivery System: Recent Strategies for the Treatment of Ocular Disease and Future Perspective", RECENT PATENTS ON DRUG DELIVERY & FORMULATION, BENTHAM SCIENCE PUBLISHERS LTD., NL, vol. 13, no. 4, 29 April 2020 (2020-04-29), NL , pages 246 - 254, XP055932178, ISSN: 1872-2113, DOI: 10.2174/1872211314666191224115211
NAGAI NORIAKI, ITO YOSHIMASA, OKAMOTO NORIO, SHIMOMURA YOSHIKAZU: "A nanoparticle formulation reduces the corneal toxicity of indomethacin eye drops and enhances its corneal permeability", TOXICOLOGY, LIMERICK, IR, vol. 319, 1 May 2014 (2014-05-01), IR , pages 53 - 62, XP055932180, ISSN: 0300-483X, DOI: 10.1016/j.tox.2014.02.012
QIU FANGFANG, MENG TUO, CHEN QIAN, ZHOU KELU, SHAO YAN, MATLOCK GREG, MA XIANG, WU WENJING, DU YANHONG, WANG XIANG, DENG GUOTAO, M: "Fenofibrate-Loaded Biodegradable Nanoparticles for the Treatment of Experimental Diabetic Retinopathy and Neovascular Age-Related Macular Degeneration", MOLECULAR PHARMACEUTICS, AMERICAN CHEMICAL SOCIETY, US, vol. 16, no. 5, 6 May 2019 (2019-05-06), US , pages 1958 - 1970, XP055932182, ISSN: 1543-8384, DOI: 10.1021/acs.molpharmaceut.8b01319
GOTO RYOKA, TAIJI NAGAOKA, SAORI DEGUCHI, TAIKOU MORIMOTO, HIROKO OTAKE, NORIAKI NAGAI: "29P01-278S: Design of ophthalmic formulation containingFenofibrate solid nanoparticles for the retinal drug delivery", ABSTRACTS OF THE ANNUAL MEETING OF THE JAPANESE SOCIETY OF PHARMACEUTICAL SCIENCES, JAPANESE SOCIETY OF PHARMACEUTICAL SCIENCES, JP, 1 March 2021 (2021-03-01) - 29 March 2021 (2021-03-29), JP, pages 29P01 - 278S, XP055932194
NAGAI NORIAKI: "Evaluation Based on Pharmaceutical Characteristics and Design of Novel Nanomedicine in the Ophthalmic Field", IRYO YAKUGAKU - JAPANESE JOURNAL OF PHARMACEUTICAL HEALTH CAREAND SCIENCES, NIHON BYOIN YAKUZAISHIKAI, TOKYO, JP, vol. 44, no. 10, 10 October 2018 (2018-10-10), JP , pages 481 - 490, XP055932154, ISSN: 1346-342X, DOI: 10.5649/jjphcs.44.481
OTAKE HIROKO, YU MANO, NORIAKI NAGAI: "Development of Nano Ophthalmic Formulation for Improving Intraocular Drug Delivery", THE JOURNAL OF THE JAPANESE SOCIETY FOR CATARACT RESEARCH, vol. 31, no. 1, 1 January 2019 (2019-01-01), pages 33 - 35, XP055932174, ISSN: 0915-4302, DOI: 10.14938/cataract.11-007
QAMAR ZUFIKA, QIZILBASH FARHEEN FATIMA, IQUBAL MOHAMMAD KASHIF, ALI ASGAR, NARANG JASJEET KAUR, ALI JAVED, BABOOTA SANJULA: "Nano-Based Drug Delivery System: Recent Strategies for the Treatment of Ocular Disease and Future Perspective", RECENT PATENTS ON DRUG DELIVERY & FORMULATION, BENTHAM SCIENCE PUBLISHERS LTD., NL, vol. 13, no. 4, 29 April 2020 (2020-04-29), NL , pages 246 - 254, XP055932178, ISSN: 1872-2113, DOI: 10.2174/1872211314666191224115211
NAGAI NORIAKI, ITO YOSHIMASA, OKAMOTO NORIO, SHIMOMURA YOSHIKAZU: "A nanoparticle formulation reduces the corneal toxicity of indomethacin eye drops and enhances its corneal permeability", TOXICOLOGY, LIMERICK, IR, vol. 319, 1 May 2014 (2014-05-01), IR , pages 53 - 62, XP055932180, ISSN: 0300-483X, DOI: 10.1016/j.tox.2014.02.012
QIU FANGFANG, MENG TUO, CHEN QIAN, ZHOU KELU, SHAO YAN, MATLOCK GREG, MA XIANG, WU WENJING, DU YANHONG, WANG XIANG, DENG GUOTAO, M: "Fenofibrate-Loaded Biodegradable Nanoparticles for the Treatment of Experimental Diabetic Retinopathy and Neovascular Age-Related Macular Degeneration", MOLECULAR PHARMACEUTICS, AMERICAN CHEMICAL SOCIETY, US, vol. 16, no. 5, 6 May 2019 (2019-05-06), US , pages 1958 - 1970, XP055932182, ISSN: 1543-8384, DOI: 10.1021/acs.molpharmaceut.8b01319
GOTO RYOKA, TAIJI NAGAOKA, SAORI DEGUCHI, TAIKOU MORIMOTO, HIROKO OTAKE, NORIAKI NAGAI: "29P01-278S: Design of ophthalmic formulation containingFenofibrate solid nanoparticles for the retinal drug delivery", ABSTRACTS OF THE ANNUAL MEETING OF THE JAPANESE SOCIETY OF PHARMACEUTICAL SCIENCES, JAPANESE SOCIETY OF PHARMACEUTICAL SCIENCES, JP, 1 March 2021 (2021-03-01) - 29 March 2021 (2021-03-29), JP, pages 29P01 - 278S, XP055932194
Attorney, Agent or Firm:
NISHIZAWA Kazuyoshi et al. (JP)
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