Title:
FACTOR XIa INHIBITORS
Document Type and Number:
WIPO Patent Application WO/2016/015593
Kind Code:
A1
Abstract:
The present invention provides a compound of Formula (I) and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing thromboses, embolisms, hypercoagulability or fibrotic changes. The compounds are selective Factor XIa inhibitors or dual inhibitors of Factor XIa and plasma kallikrein.
Inventors:
LIU WEIGUO (US)
EDMONDSON SCOTT D (US)
GUO ZHUYAN (US)
SO SUNG-SAU (US)
OGAWA ANTHONY K (US)
KUANG RONGZE (US)
WU HEPING (US)
ALI AMJAD (US)
GAO YING-DUO (US)
JIANG YU (US)
LI CHUNSING (CN)
YU TINGTING (CN)
PANDYA BHUAMIK (US)
LIPPA BLAISE (US)
ZHANG XIN (US)
BABER JON CHRISTIAN (US)
ROMERO JAN ANTOINETTE C (US)
ZHANG JING (US)
EDMONDSON SCOTT D (US)
GUO ZHUYAN (US)
SO SUNG-SAU (US)
OGAWA ANTHONY K (US)
KUANG RONGZE (US)
WU HEPING (US)
ALI AMJAD (US)
GAO YING-DUO (US)
JIANG YU (US)
LI CHUNSING (CN)
YU TINGTING (CN)
PANDYA BHUAMIK (US)
LIPPA BLAISE (US)
ZHANG XIN (US)
BABER JON CHRISTIAN (US)
ROMERO JAN ANTOINETTE C (US)
ZHANG JING (US)
Application Number:
PCT/CN2015/084937
Publication Date:
February 04, 2016
Filing Date:
July 23, 2015
Export Citation:
Assignee:
MERCK SHARP & DOHME (US)
LIU WEIGUO (US)
EDMONDSON SCOTT D (US)
GUO ZHUYAN (US)
SO SUNG-SAU (US)
OGAWA ANTHONY K (US)
KUANG RONGZE (US)
WU HEPING (US)
ALI AMJAD (US)
GAO YING-DUO (US)
JIANG YU (US)
LI CHUNSING (CN)
YU TINGTING (CN)
PANDYA BHUAMIK (US)
LIPPA BLAISE (US)
ZHANG XIN (US)
BABER JON CHRISTIAN (US)
ROMERO JAN ANTOINETTE C (US)
ZHANG JING (US)
LIU WEIGUO (US)
EDMONDSON SCOTT D (US)
GUO ZHUYAN (US)
SO SUNG-SAU (US)
OGAWA ANTHONY K (US)
KUANG RONGZE (US)
WU HEPING (US)
ALI AMJAD (US)
GAO YING-DUO (US)
JIANG YU (US)
LI CHUNSING (CN)
YU TINGTING (CN)
PANDYA BHUAMIK (US)
LIPPA BLAISE (US)
ZHANG XIN (US)
BABER JON CHRISTIAN (US)
ROMERO JAN ANTOINETTE C (US)
ZHANG JING (US)
International Classes:
C07D233/54; A61K31/4164; A61K31/4192; A61K31/422; A61K31/433; A61P7/02; C07D249/06; C07D257/06; C07D263/30; C07D271/10; C07D285/04
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| WO2013093484A1 | 2013-06-27 | |||
| WO2008076805A2 | 2008-06-26 | |||
| WO2014160592A2 | 2014-10-02 | |||
| WO2013022814A1 | 2013-02-14 | |||
| WO2013022818A1 | 2013-02-14 | |||
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J. ORG. CHEM., vol. 69, 2004, pages 250 - 262
COLEMAN, R.: "Hemostasis and Thrombosis", 2001, LIPPINCOTT WILLIAMS & WILKINS, article "Contact Activation Pathway", pages: 103 - 122
SCHMAIER, A.H.: "Contact Activation", THROMBOSIS AND HEMORRHAGE, 1998, pages 105 - 128
RENNE ET AL., J EXP. MED., vol. 202, 2005, pages 271 - 281
KLEINSCHMITZ ET AL., J EXP. MED., vol. 203, 2006, pages 513 - 518
SCHNEIDER, L ET AL., J.ALLERGY CLIN.IMMUNOL., vol. 120, 2007, pages 416
A. CLERMONT ET AL., DIABETES, vol. 60, 2011, pages 1590
DIASS, J. O. ET AL., ORGANOMETALLICS, vol. 5, 2006, pages 1188 - 1198
SHOWELL, G.A. ET AL., BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 16, 2006, pages 2555 - 2558
CHOUTALALAY, ADV. ENZYME REGUL., vol. 22, 1984, pages 27 - 55
HAJRI, MAJDIBLONDELLE, CLEMENTMARTINEZ, AGATHEVASSE, JEAN-LUCSZYMONIAK, JAN TETRAHEDRON LETTERS, vol. 54, no. 8, 2013, pages 1029 - 1031
PURE APPL. CHEM., vol. 63, 1991, pages 419 - 422
J. AM. CHEM. SOC., vol. 122, 2000, pages 4020 - 4028
DENG, LISHENGSUNDRIYAL, SANDEEPRUBIO, VALENTINASHI, ZHENG-ZHENGSONG, YONGCHENG, JOURNAL OF MEDICINAL CHEMISTRY, vol. 52, no. 21, 2009, pages 6539 - 6542
J. ORG. CHEM., vol. 69, 2004, pages 250 - 262
Attorney, Agent or Firm:
WU, FENG & ZHANG CO. (CN)
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