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Title:
FGF RECEPTOR-ACTIVATING N-SULFATE OLIGOSACCHARIDES, PREPARATION THEREOF, AND THERAPEUTIC USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2011/018587
Kind Code:
A3
Abstract:
The invention relates to FGF receptor-activating N-sulfate oligosaccharides having Formula (I), wherein R1, R4, R6, and R8 are -OSO3- or hydroxyl groups, R2 is an -O-alkyl group or a monosaccharide having Formula (II), R3 is a disaccharide having Formula (III), R5 is a disaccharide having Formula (IV), R7 is a hydroxyl group or a disaccharide having Formula (VI), and R9 is a hydroxyl or -O-alkyl group or a disaccharide having Formula (VII), where R10 is an -O-alkyl group. The invention further relates to the preparation of said oligosaccharides and to the therapeutic use thereof.

Inventors:
DUCHAUSSOY PHILIPPE (FR)
FONS PIERRE (FR)
FROIDBISE ALEXANDRE (FR)
Application Number:
PCT/FR2010/051702
Publication Date:
July 07, 2011
Filing Date:
August 12, 2010
Export Citation:
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Assignee:
SANOFI AVENTIS (FR)
DUCHAUSSOY PHILIPPE (FR)
FONS PIERRE (FR)
FROIDBISE ALEXANDRE (FR)
International Classes:
A61K31/737; C07H13/04; C07H13/12; C07H15/203; C08B37/00
Domestic Patent References:
WO1992018546A11992-10-29
Foreign References:
FR2800074A12001-04-27
US20040068108A12004-04-08
Other References:
CODEE J D C ET AL: "The synthesis of well-defined heparin and heparan sulfate fragments", DRUG DISCOVERY TODAY: TECHNOLOGIES, ELSEVIER, vol. 1, no. 3, 1 December 2004 (2004-12-01), pages 317 - 326, XP004767969, ISSN: 1740-6749
C. TABEUR ET AL.: "Oligosaccharides corresponding to the regular sequence of heparin: chemical synthesis and interaction with FGF-2", BIOORGANIC & MEDICINAL CHEMISTRY, vol. 7, 1999, pages 2003 - 2012, XP002575365
Attorney, Agent or Firm:
BOURON, Estelle (Département Brevets174 avenue de France, Paris, FR)
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