Title:
FLUORESCENT COMPOUND AND FLUORESCENT-LABELED BIOLOGICAL SUBSTANCE USING SAME
Document Type and Number:
WIPO Patent Application WO/2022/191123
Kind Code:
A1
Abstract:
A fluorescent compound of the following formula or a salt thereof, and a labeled biological substance. Y represents -NR10R11 or -OR12, R1-R12, R21-R23, and Z represent specific groups and satisfy the following provisions. R21 and/or R22 is an alkenyl group, an alkynyl group, an aryl group, or a heteroaryl group. When R21=aryl group and R22=alkyl group or aryl group, R7 and R8 and/or R10 and R11 bond to form a 4-membered ring. A compound of formula (I) or (II) or salt thereof satisfies condition α, and a compound of formula (III) or (IV) or salt thereof satisfies condition β. (Condition α) When an aryl group, Z has a specific structure. (Condition β) R7 and R8 and/or R10 and R11 bond to form a 4-membered ring.
Inventors:
SAKAKIBARA MASATO (JP)
NAKATA HIYOKU (JP)
TANAKA HIROAKI (JP)
NAKATA HIYOKU (JP)
TANAKA HIROAKI (JP)
Application Number:
PCT/JP2022/009678
Publication Date:
September 15, 2022
Filing Date:
March 07, 2022
Export Citation:
Assignee:
FUJIFILM CORP (JP)
International Classes:
C07F7/10; C07F9/6568; G01N21/64; G01N33/58
Domestic Patent References:
| WO2020033681A2 | 2020-02-13 |
Foreign References:
| JP2018090536A | 2018-06-14 | |||
| JP6462587B2 | 2019-01-30 | |||
| JP2021123624A | 2021-08-30 |
Other References:
DATABASE REGISTRY 2 July 2020 (2020-07-02), ANONYMOUS : "-Azetidinium, 1-[7-(1-azetidinyl)-10-(2,6-dimethoxyphenyl)-5-oxido-5-phenyl- 3(5H)-acridophosphinylidene]-(CA INDEX NAME)", XP055964937, retrieved from STN Database accession no. 2440069-49-6 (+ 2411339-57-4, 2411339-55-2, 2410073-80-0, 2410073-74-2)
GRIMM JONATHAN B.; TKACHUK ARIANA N.; XIE LIANGQI; CHOI HEEJUN; MOHAR BOAZ; FALCO NATALIE; SCHAEFER KATHY; PATEL RONAK; ZHENG QINS: "A general method to optimize and functionalize red-shifted rhodamine dyes", NATURE METHODS, NATURE PUBLISHING GROUP US, NEW YORK, vol. 17, no. 8, 27 July 2020 (2020-07-27), New York, pages 815 - 821, XP037208351, ISSN: 1548-7091, DOI: 10.1038/s41592-020-0909-6
GRZYBOWSKI MAREK, MASAYASU TAKI, KEIJI KAJIWARA, SHIGEHIRO YAMAGUCHI: "Effects of Amino Group Substitution on the Photophysical Properties and Stability of Near-Infrared Fluorescent P-Rhodamines", CHEM. EUR. J., vol. 26, no. 35, 10 April 2020 (2020-04-10), pages 7912 - 7917, XP055964934, DOI: 10.1002/chem.202000957
SAUER MARIA, NASUFOVIC VESELIN, ARNDT HANS-DIETER, VILOTIJEVIC IVAN: "Robust synthesis of NIR-emissive P-rhodamine fluorophores", ORGANIC & BIOMOLECULAR CHEMISTRY, ROYAL SOCIETY OF CHEMISTRY, vol. 18, no. 8, 26 February 2020 (2020-02-26), pages 1567 - 1571, XP055964932, ISSN: 1477-0520, DOI: 10.1039/D0OB00189A
GRIMM JONATHAN B., BROWN TIMOTHY A., TKACHUK ARIANA N., LAVIS LUKE D.: "General Synthetic Method for Si-Fluoresceins and Si-Rhodamines", ACS CENTRAL SCIENCE, vol. 3, no. 9, 27 September 2017 (2017-09-27), pages 975 - 985, XP055964931, ISSN: 2374-7943, DOI: 10.1021/acscentsci.7b00247
GRIMM JONATHAN B.; TKACHUK ARIANA N.; XIE LIANGQI; CHOI HEEJUN; MOHAR BOAZ; FALCO NATALIE; SCHAEFER KATHY; PATEL RONAK; ZHENG QINS: "A general method to optimize and functionalize red-shifted rhodamine dyes", NATURE METHODS, NATURE PUBLISHING GROUP US, NEW YORK, vol. 17, no. 8, 27 July 2020 (2020-07-27), New York, pages 815 - 821, XP037208351, ISSN: 1548-7091, DOI: 10.1038/s41592-020-0909-6
GRZYBOWSKI MAREK, MASAYASU TAKI, KEIJI KAJIWARA, SHIGEHIRO YAMAGUCHI: "Effects of Amino Group Substitution on the Photophysical Properties and Stability of Near-Infrared Fluorescent P-Rhodamines", CHEM. EUR. J., vol. 26, no. 35, 10 April 2020 (2020-04-10), pages 7912 - 7917, XP055964934, DOI: 10.1002/chem.202000957
SAUER MARIA, NASUFOVIC VESELIN, ARNDT HANS-DIETER, VILOTIJEVIC IVAN: "Robust synthesis of NIR-emissive P-rhodamine fluorophores", ORGANIC & BIOMOLECULAR CHEMISTRY, ROYAL SOCIETY OF CHEMISTRY, vol. 18, no. 8, 26 February 2020 (2020-02-26), pages 1567 - 1571, XP055964932, ISSN: 1477-0520, DOI: 10.1039/D0OB00189A
GRIMM JONATHAN B., BROWN TIMOTHY A., TKACHUK ARIANA N., LAVIS LUKE D.: "General Synthetic Method for Si-Fluoresceins and Si-Rhodamines", ACS CENTRAL SCIENCE, vol. 3, no. 9, 27 September 2017 (2017-09-27), pages 975 - 985, XP055964931, ISSN: 2374-7943, DOI: 10.1021/acscentsci.7b00247
Attorney, Agent or Firm:
IIDA & PARTNERS et al. (JP)
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