Title:
FLUORINATED PHENYL THIOPHENYL DERIVATIVES AND THEIR USE FOR IMAGING SEROTONIN TRANSPORTERS
Document Type and Number:
WIPO Patent Application WO2003078393
Kind Code:
A3
Abstract:
This invention relates to novel fluorinated phenyl thiphenyl (also named diarylsulfide) derivatives and their use in Positron Emission Tomagraphy (PET) imaging of Serotonin Transporters (SERTS). The present invention also provides diagnostic compositions comprising the novel compounds of the present invention, and a pharmaceutically acceptable carrier or diluent. The invention further provides a method of imaging SERTS, comprising introducing into a patient a detectable quantity of a labeled compound of the present invention, or a pharmaceutically acceptable salt, ester, amide or prodrug thereof.
Inventors:
KUNG HANK F (US)
SHIUE CHYNG-YANN (US)
OYA SHUNICHI (US)
CHOI SEOK RYE (US)
SHIUE GRACE G (US)
FANG PING (US)
SHIUE CHYNG-YANN (US)
OYA SHUNICHI (US)
CHOI SEOK RYE (US)
SHIUE GRACE G (US)
FANG PING (US)
Application Number:
PCT/US2003/007935
Publication Date:
April 15, 2004
Filing Date:
March 14, 2003
Export Citation:
Assignee:
KUNG HANK F (US)
SHIUE CHYNG-YANN (US)
UNIV PENNSYLVANIA (US)
OYA SHUNICHI (US)
CHOI SEOK RYE (US)
SHIUE GRACE G (US)
FANG PING (US)
SHIUE CHYNG-YANN (US)
UNIV PENNSYLVANIA (US)
OYA SHUNICHI (US)
CHOI SEOK RYE (US)
SHIUE GRACE G (US)
FANG PING (US)
International Classes:
A61K51/04; C07C323/32; C07C323/37; (IPC1-7): A61K51/00; C07C321/24
Other References:
OYA ET AL.: "New PET imaginf for the serotonin transporter: (18)ACF (2-((2-amino-4-chloro-5-fluorophenyl)thio)-N,N-dimethyl-benzenmethanamine)", JOURNAL OF MEDICINAL CHEMISTRY, vol. 45, 2002, pages 4716 - 4723, XP002966178
DATABASE CAPLUS [online] "Preparation of agents for serotonin transporter SPECT imaging", XP002966174, accession no. STN Database accession no. 2000-790459
DATABASE CAPLUS [online] "Preparation of diphenyl sulfides as nervous system agents", XP002966175, accession no. STN Database accession no. 1991-228508
DATABASE CAPLUS [online] "A new single -photon emission computed tomography imaging agent for serotonin transporters: (1231) IDAM, 50Iodo-2((2-((dimethylamino)methyl)phenyl)thio) benzyl alcohol", XP002966176, accession no. STN Database accession no. 1999-59445
DATABASE CAPLUS [online] BLIN ET AL.: "(18F)setoperone: a new high affinity ligand for positron emission tomography study of serotonin-2 receptors in baboon brain in vivo", XP002966177, accession no. STN Database accession no. 1988-164322
DATABASE CAPLUS [online] SUEHIRO ET AL.: "Radiosynthesis and biodistribution of the S-(18F) fluoroethyl analog of McN5652", XP002967302, accession no. STN Database accession no. 1996-580805
DATABASE CAPLUS [online] "Preparation of agents for serotonin transporter SPECT imaging", XP002966174, accession no. STN Database accession no. 2000-790459
DATABASE CAPLUS [online] "Preparation of diphenyl sulfides as nervous system agents", XP002966175, accession no. STN Database accession no. 1991-228508
DATABASE CAPLUS [online] "A new single -photon emission computed tomography imaging agent for serotonin transporters: (1231) IDAM, 50Iodo-2((2-((dimethylamino)methyl)phenyl)thio) benzyl alcohol", XP002966176, accession no. STN Database accession no. 1999-59445
DATABASE CAPLUS [online] BLIN ET AL.: "(18F)setoperone: a new high affinity ligand for positron emission tomography study of serotonin-2 receptors in baboon brain in vivo", XP002966177, accession no. STN Database accession no. 1988-164322
DATABASE CAPLUS [online] SUEHIRO ET AL.: "Radiosynthesis and biodistribution of the S-(18F) fluoroethyl analog of McN5652", XP002967302, accession no. STN Database accession no. 1996-580805
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