PREPARATION OF N1-(2'-PYRIDYL)-1,2-PROPANEDIAMINE SULFAMIC ACID AND ITS USE IN THE SYNTHESIS OF BIOLOGICALLY ACTIVE PIPERAZINES

Title:

PREPARATION OF N1-(2'-PYRIDYL)-1,2-PROPANEDIAMINE SULFAMIC ACID AND ITS USE IN THE SYNTHESIS OF BIOLOGICALLY ACTIVE PIPERAZINES

Document Type and Number:

WIPO Patent Application WO2003078396

Kind Code:

A8

Abstract:

A process for making an N1-(2'-pyridyl)-1,2-alkanediamine sulfamic acid of formula (II) by reacting a compound of formula (I) with NH2R', wherein R and R' are as defined in the specification. The invention also includes the compound of formula (II), and optical isomers thereof. The compound of formula (II) is an intermediate useful for making chiral piperazine derivatives which are active at the 5-HT1A receptor.

Inventors:

CHAN ANITA WAI-YIN (US)
FEIGELSON GREGG BRIAN (US)
ZELDIS JOSEPH (US)
JIRKOVSKY IVO (US)

Application Number:

PCT/US2003/007228

Publication Date:

January 29, 2004

Filing Date:

March 10, 2003

Export Citation:

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Assignee:

WYETH CORP (US)
CHAN ANITA WAI-YIN (US)
FEIGELSON GREGG BRIAN (US)
ZELDIS JOSEPH (US)
JIRKOVSKY IVO (US)

International Classes:

A61P25/00; C07D213/74; C07D213/75; C07D213/76; C07D405/12; (IPC1-7): C07D213/76; C07D213/74; C07D213/75; C07D405/12; A61K31/44; A61P25/00

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