FLUORINE-CONTAINING 5-[2-(PYRID-3-YL)-ETHYL]-2,3,4-TETRAHYDRO-1Н-PYRIDO[4,3-B]INDOLES AS AGENTS FOR REDUCING UNCONTROLLED PROTEIN AGGREGATION - FEDERALNOE G BUDZHETNOE UCHREZHDENIE NAUKI INST FIZIOL AKTIVNYKH VESHCHESTV RAN IFAV RAN

Title:

FLUORINE-CONTAINING 5-[2-(PYRID-3-YL)-ETHYL]-2,3,4-TETRAHYDRO-1Н-PYRIDO[4,3-B]INDOLES AS AGENTS FOR REDUCING UNCONTROLLED PROTEIN AGGREGATION

Document Type and Number:

WIPO Patent Application WO/2013/070117

Kind Code:

A3

Abstract:

The claimed fluorine-containing substituted 5-[2-(pyrid-3-yl)-ethyl]-2,3,4-tetrahydro-1H-pyrido[4,3-b]indoles and hydrochlorides and hydrobromides thereof, which have the general formula (I), as agents for reducing uncontrolled protein aggregation in the nervous system, the pharmacological agent based thereon and the method for using same relate to the field of medicine and solve the problem of increasing the range of agents for combating the development of destructive processes in the central and peripheral nervous system. Formula (I), where R1 = R2 = R4 = Н, Me; or R4 + R2 = -СН2-СН2-; R3 = Н, (C1-С6) alkyl, (С2-С6) alkenyl, (Сз-С6) alkynyl, (C1-C6) alkoxy (C1-C6) alkyl, [F, Cl, Br, NO2, (C1-C6) alkyl, (C1-C6) alkoxy, acyl, (C1-C6) alkylsulfonyl, (C1- С6) alkoxycarbonyl - substituted] aryloxy (C1-C6) alkyl, (С3-С7) cycloalkyl, [F, Сl, Вr, NO2, (C1-C6) alkyl, (C1-C6) alkoxy, acyl, (C1-C6) alkylsulfonyl, (С1-С6) alkoxycarbonyl - substituted] aryl, heteryl, (C1-C6) alkylsulfonyl, (C1-C6) alkoxycarbonyl, (C1-С6) acyl, [F, Cl, Br, NO2, (С1-С6) alkyl, (C1-C6) alkoxy, acyl, (C1- С6) alkylsulfonyl, (C1-C6) alkoxycarbonyl - substituted] aroyl, heteroyl, Ν,Ν-dialkylcarbamoyl, Ν,Ν-dialkylaminosulfonyl; R5, R6, R7, R8 = H, F, Cl, Br, CN, OH, CF3, CF3O, CHF2O, NO2, (C1-C6) alkyl, (C3-C7) cycloalkyl, (C1-C6) alkoxy, [F, Cl, Br, NO2, (C1-C6) alkyl, (C1-C6) alkoxy, acyl, (C1-C6) alkylsulfonyl, (C1-C6) alkoxycarbonyl - substituted] aryl, [F, Cl, Br, NO2, (C1-C6) alkyl, (C1-С6) alkoxy, acyl, (C1-C6) alkylsulfonyl, (C1-C6) alkoxycarbonyl - substituted] aryloxy, (Me, Cl, Br - substituted) pyridyl, (C1-C6) alkylsulfonyl, (C1- С6) alkoxycarbonyl, (C1-C6) acyl, [F, Cl, Br, NO2, (C1-C6) alkyl, (C1-C6) alkoxy, acyl, (C1-C6) alkylsulfonyl, (C1-C6) alkoxycarbonyl - substituted] aroyl, Ν,Ν-dialkylcarbamoyl, Ν,Ν-dialkylaminosulfonyl; R9 = F, 2F, CHF2, CC1F2, CF3.; X = nothing, Cl. Br.

Inventors:

BACHURIN SERGEY OLEGOVICH (RU)
USTUGOV ALEKSEY ANATOLYEVICH (RU)
NINKINA NATALYA NIKOLAEVNA (RU)
SOKOLOV VLADIMIR BORISOVICH (RU)
AKSINENKO ALEKSEY YURYEVICH (RU)
SHELKOVNIKOVA TATYANA ALEKSANDROVNA (RU)
BOLKUNOV ALEKSEY VIKTOROVICH (RU)

Application Number:

PCT/RU2012/000894

Publication Date:

July 18, 2013

Filing Date:

November 01, 2012

Export Citation:

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Assignee:

FEDERALNOE G BUDZHETNOE UCHREZHDENIE NAUKI INST FIZIOL AKTIVNYKH VESHCHESTV RAN IFAV RAN (RU)

International Classes:

C07D471/04; A61K31/407; A61P25/00

Domestic Patent References:

WO2009038764A1	2009-03-26
WO2010127177A1	2010-11-04
WO2009055828A1	2009-04-30
WO2009120720A1	2009-10-01
WO2011038164A1	2011-03-31

Other References: