Title:
FORMULATIONS CONTAINING PROPOFOL AND A SULFOALKYL ETHER CYCLODEXTRIN
Document Type and Number:
WIPO Patent Application WO2002074200
Kind Code:
B1
Abstract:
An injectable formulation of a sedative hypnotic drug, such as the anesthetic drug propofol, that is pharmaceutically stable and demonstrates a reduced incidence of pain upon injection. The formulation of the present invention employs a sulfoalkyl sther cyclodextrin solubilizing and complexing excipient, such as CAPTISOL3 cyclodextrin (sulfobutyl ether beta -cyclodextrin) to form a true aqueous solution and not a suspension. This formulation minimizes the allergic response and microbial contamination issues typically associated with propofol parenteral formulations. The present formulation may also reduce pain on injection as compared to the known emulsion type propofol formulations. The liquid formulation can be sterile filtered unlike emulsion-type formulations of sedative hypnotics. The liquid formulation can be lyophilized or otherwise dried to yield a solid formulation.
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Inventors:
MOSHER GEROLD L (US)
THOMPSON DIANE O (US)
THOMPSON DIANE O (US)
Application Number:
PCT/US2002/008596
Publication Date:
March 06, 2003
Filing Date:
March 19, 2002
Export Citation:
Assignee:
CYDEX INC (US)
MOSHER GEROLD L (US)
THOMPSON DIANE O (US)
MOSHER GEROLD L (US)
THOMPSON DIANE O (US)
International Classes:
A61K9/08; A61K31/05; A61K31/167; A61K31/245; A61K31/445; A61K31/4453; A61K31/4704; A61K31/724; A61K47/40; A61K47/48; A61P23/02; A61P25/20; C08B37/16; (IPC1-7): A61F2/02
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