Title:
FORMULATIONS FOR TREATING OR PREVENTING MUCOSITIS
Document Type and Number:
WIPO Patent Application WO2001019362
Kind Code:
A3
Abstract:
Mucositis is treated and/or prevented by administrating to a patient a formulation comprising a tetracycline that is poorly absorbed from the gastro-intestinal tract. The tetracycline may be in the form of a pharmaceutically acceptable salt or a base. The formulations may optionally also contain an antifungal agent to prevent fungal overgrowth due to reduction in the normal oral flora by the tetracycline. Such compositions have the advantage of treating the entire gastro-intestinal tract since the active ingredient is not removed from the tract via absorption. Further, such compositions minimize systemic exposure and accompanying side effects.
Inventors:
LAWTER JAMES RONALD
COMISKEY STEPHEN J
COMISKEY STEPHEN J
Application Number:
PCT/US2000/040907
Publication Date:
December 13, 2001
Filing Date:
September 14, 2000
Export Citation:
Assignee:
ORAPHARMA INC (US)
International Classes:
A61K9/00; A61K9/12; A61K9/06; A61K9/20; A61K9/50; A61K31/196; A61K31/65; A61P1/02; A61P1/04; A61P29/00; A61K9/16; A61K47/36; (IPC1-7): A61K31/166; A61P17/00
Domestic Patent References:
| WO2000007601A1 | 2000-02-17 | |||
| WO1999022703A1 | 1999-05-14 | |||
| WO1994027579A1 | 1994-12-08 |
Foreign References:
| US5981499A | 1999-11-09 | |||
| US5827840A | 1998-10-27 |
Other References:
ROTHWELL: "palliation of radiatiomn-mediated mucositis", SPECIAL CARE IN DENTISTRY, vol. 10, no. 1, 1990, pages 21 - 25, XP002111630
SCHENK: "controlled local delivery...", CLINICAL ORAL IMPLANTS RE., vol. 8, no. 5, 1997, pages 427 - 433, XP002111646
FACCHINI: "activity of topical...", MINERVA GINECOL., vol. 41, no. 12, 1989, pages 609 - 614, XP001023170
CUTLER ALAN F ET AL: "Patient factors affecting Helicobacter pylori eradication with triple therapy.", AMERICAN JOURNAL OF GASTROENTEROLOGY, vol. 88, no. 4, 1993, pages 505 - 509, XP001016477, ISSN: 0002-9270
FRANCESCHI D ET AL: "SOLITARY J-POUCH ULCER CAUSING POUCHITIS-LIKE SYNDROME", DISEASES OF THE COLON AND RECTUM, vol. 29, no. 8, 1986, pages 515 - 517, XP001016486, ISSN: 0012-3706
SCHENK: "controlled local delivery...", CLINICAL ORAL IMPLANTS RE., vol. 8, no. 5, 1997, pages 427 - 433, XP002111646
FACCHINI: "activity of topical...", MINERVA GINECOL., vol. 41, no. 12, 1989, pages 609 - 614, XP001023170
CUTLER ALAN F ET AL: "Patient factors affecting Helicobacter pylori eradication with triple therapy.", AMERICAN JOURNAL OF GASTROENTEROLOGY, vol. 88, no. 4, 1993, pages 505 - 509, XP001016477, ISSN: 0002-9270
FRANCESCHI D ET AL: "SOLITARY J-POUCH ULCER CAUSING POUCHITIS-LIKE SYNDROME", DISEASES OF THE COLON AND RECTUM, vol. 29, no. 8, 1986, pages 515 - 517, XP001016486, ISSN: 0012-3706
Download PDF:
Previous Patent: THERAPEUTIC USES OF POLYMERS AND OLIGOMERS COMPRISING GAMMA-HYDROXYBUTYRATE
Next Patent: PHARMACEUTICAL AND/OR COSMETICAL COMPOSITIONS
Next Patent: PHARMACEUTICAL AND/OR COSMETICAL COMPOSITIONS