Title:
THERAPEUTIC USES OF POLYMERS AND OLIGOMERS COMPRISING GAMMA-HYDROXYBUTYRATE
Document Type and Number:
WIPO Patent Application WO2001019361
Kind Code:
A3
Abstract:
Oligomers and polymer compositions are provided which comprise GHB and produce GHB after administration in vivo. Devices for the storage and delivery of these polymers and oligomers are also provided. These oligomers and polymer compositions are useful in a variety of applications. The compositions can be used therapeutically, for example, in the treatment of patients with narcolepsy, chronic schizophrenia, catatonic schizophrenia, atypical psychoses, chronic brain syndrome, neurosis, alcoholism, drug addiction and withdrawal, Parkinson's disease and other neuropharmacological illnesses, hypertension, ischemia, circulatory collapse, radiation exposure, cancer, and myocardial infarction. Other uses for the compositions include anesthesia induction, sedation, growth hormone production, heightened sexual desire, anorectic effects, euphoria, smooth muscle relaxation, muscle mass production, and sleep, including rapid eye movement sleep. In a still further embodiment, the oligomers and polymers may be used to produce absence seizures.
Inventors:
WILLIAMS SIMON F
MARTIN DAVID P
MARTIN DAVID P
Application Number:
PCT/US2000/025261
Publication Date:
October 04, 2001
Filing Date:
September 14, 2000
Export Citation:
Assignee:
TEPHA INC (US)
METABOLIX INC (US)
METABOLIX INC (US)
International Classes:
A61K31/19; A61K31/765; A61P5/00; A61P9/10; A61P9/12; A61P15/00; A61P21/02; A61P23/00; A61P25/16; A61P25/18; A61P25/20; A61P25/32; A61P29/00; A61P35/00; A61P43/00; (IPC1-7): A61K31/19; A61K31/765; A61P25/00; A61P25/18; A61P25/26; A61P25/32
Domestic Patent References:
| WO1999032536A1 | 1999-07-01 | |||
| WO1997030042A1 | 1997-08-21 | |||
| WO1997015681A1 | 1997-05-01 |
Foreign References:
| US5753708A | 1998-05-19 | |||
| EP0344704A1 | 1989-12-06 | |||
| EP0429403A2 | 1991-05-29 |
Other References:
REYNOLDS J. E. F.: "MARTINDALE The Extra Pharmacopoeia (Thirty First Edition)", 1996, ROYAL PHARMACEUTICAL SOCIETY, LONDON, XP002163280
ABATE ROSARIA ET AL.: "Separation and Structural Characterization of Cyclic and Open Chain Oligomers Produced in the Partial Pyrolysis of Microbial Poly(hydroxybutyrates)", MACROMOLECULES, vol. 28, no. 23, 1995, pages 7911 - 7916, XP002163279
ABATE ROSARIA ET AL.: "Separation and Structural Characterization of Cyclic and Open Chain Oligomers Produced in the Partial Pyrolysis of Microbial Poly(hydroxybutyrates)", MACROMOLECULES, vol. 28, no. 23, 1995, pages 7911 - 7916, XP002163279
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