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Title:
FOSPHENYTOIN SODIUM SOLID COMPOSITION, LYOPHILIZATION METHOD, AND USE OF FOSPHENYTOIN SODIUM SOLID COMPOSITION
Document Type and Number:
WIPO Patent Application WO/2022/116134
Kind Code:
A1
Abstract:
A fosphenytoin sodium solid composition, a lyophilization method for fosphenytoin sodium, and a use of the fosphenytoin sodium solid composition. The fosphenytoin sodium solid composition comprises fosphenytoin sodium and at least one carbohydrate. The obtained fosphenytoin sodium solid composition has good stability and can be stored at room temperature. In addition, the lyophilization method for fosphenytoin sodium is short in lyophilization time, the product obtained by the method does not collapse, redissolution time is short, and moisture content satisfies the quality requirements. The fosphenytoin sodium solid composition can be used for treating epilepsy or other convulsive states.

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Inventors:
CHEN GANG (CN)
CHEN GONGZHENG (CN)
LIN SONG (US)
NELLAIAPPAN KALIAPPANADAR (US)
JAVERI INDU (US)
Application Number:
PCT/CN2020/133822
Publication Date:
June 09, 2022
Filing Date:
December 04, 2020
Export Citation:
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Assignee:
ICHUAN CREDIT PHARMACEUTICAL CO LTD (CN)
International Classes:
A61K9/19; A61K31/675; A61K47/26; A61K47/36; A61P25/08
Domestic Patent References:
WO1999004798A11999-02-04
WO1999004798A11999-02-04
Foreign References:
CN106265501A2017-01-04
CN1555805A2004-12-22
US4925860A1990-05-15
CN1608626A2005-04-27
CA2762321A12009-11-26
US4925860A1990-05-15
EP2303228B12011-11-30
US6133248A2000-10-17
Other References:
CARBOHYDRATES IN HUMAN NUTRITION: REPORT OF A JOINT FAO/WHO EXPERT CONSULTATION, 14 April 1997 (1997-04-14)
Attorney, Agent or Firm:
BEIJING TANLULAI PATENT AGENT LTD (CN)
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