FULL-TARGET ANTIGEN-PRESENTING CELL TUMOR VACCINE, AND PREPARATION METHOD THEREFOR AND APPLICATION THEREOF

Title:

FULL-TARGET ANTIGEN-PRESENTING CELL TUMOR VACCINE, AND PREPARATION METHOD THEREFOR AND APPLICATION THEREOF

Document Type and Number:

WIPO Patent Application WO/2023/274299

Kind Code:

A1

Abstract:

Provided is a full-target antigen-presenting cell (APC) tumor vaccine, and a preparation method therefor and an application thereof. The preparation method for the full-target APC tumor vaccine comprises: performing co-incubation of a quantum dot-modified tumor cell and an immature APC, wherein the quantum dot-modified tumor cell is obtained by linking a quantum dot to a protein molecular chain of a tumor cell by means of a hydrogen bond. By means of the co-incubation of the quantum dot-modified tumor cell and the immature APC, the immature APC (e.g., an MP or a DC) can be converted from an immature state to a hyperactivated state, such that uptake of tumor antigens by the APC is enhanced, MHC molecule expression is significantly upregulated, and the antigen presenting efficiency is improved.

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Inventors:

QU SONGNAN (CN)
TANG ZIKANG (CN)
ZHOU YINNING (CN)

Application Number:

PCT/CN2022/102378

Publication Date:

January 05, 2023

Filing Date:

June 29, 2022

Export Citation:

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Assignee:

UNIV MACAU (CN)

International Classes:

A61K39/00; A61K47/46; A61P35/00; C12N5/09

Foreign References:

CN113440607A	2021-09-28
CN113797356A	2021-12-17
CN105502341A	2016-04-20
CN111606319A	2020-09-01
US20200163899A1	2020-05-28
US20130195963A1	2013-08-01
CN105219383A	2016-01-06
CN105079806A	2015-11-25

Other References:

TANG ZIKANG, LIANG TAO, LEI JOSH HAIPENG, GAO HANLU, ZHOU YINNING, LIU YOUCHENG, LIU ENSHAN, ZHANG BOHAN, ZHANG HUIQI, QIAN LUO KA: "Cancer Immunotherapy Based on Carbon-Quantum- Dot Modied Cancer Cells", RESEARCH SQUARE, 26 April 2021 (2021-04-26), XP093017859, Retrieved from the Internet [retrieved on 20230125], DOI: 10.21203/rs.3.rs-457550/v1
WANG, WEI ET AL.: "Carbon nanotubes enhance the phagocytosis of tumor antigens by dendritic cells", 2010 NATIONAL SYMPOSIUM ON MOLECULAR MARKERS AND APPLICATIONS OF TUMORS AND THE 5TH CHINA YOUNG AND MIDDLE-AGED TUMOR EXPERTS FORUM PROCEEDINGS, 10 September 2010 (2010-09-10), pages 201 - 202, XP009542501

Attorney, Agent or Firm:

CHOFN INTELLECTUAL PROPERTY (CN)

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