FUSED PYRIMIDINE-BASED DERIVATIVE, METHOD FOR PREPARING SAME, AND USE THEREOF

Title:

FUSED PYRIMIDINE-BASED DERIVATIVE, METHOD FOR PREPARING SAME, AND USE THEREOF

Document Type and Number:

WIPO Patent Application WO/2023/207960

Kind Code:

A1

Abstract:

The present invention relates to a substituted fused pyrimidine-based derivative, a method for preparing same, and pharmaceutical use of a pharmaceutical composition comprising the derivative. Specifically, the present invention relates to a substituted fused pyrimidine-based derivative represented by formula (I), a method for preparing same, a pharmaceutically acceptable salt thereof, and use thereof as a therapeutic agent, particularly an HPK1 inhibitor, wherein the substituents in formula (I) are defined in the specification.

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Inventors:

ZHOU MENGGUANG (CN)
CHENG CHAOYING (CN)
HU DUFEN (CN)
LIN LINGZHI (CN)
LIN WENCHENG (CN)
XU YINGBIAO (CN)
SHAO LINJIANG (CN)
LIN CHENGCAI (CN)
YE CHENG (CN)
XU DAIWANG (CN)
ZHANG PANPAN (CN)
XU XIAOJIE (CN)

Application Number:

PCT/CN2023/090548

Publication Date:

November 02, 2023

Filing Date:

April 25, 2023

Export Citation:

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Assignee:

ZHEJIANG HISUN PHARM CO LTD (CN)
SHANGHAI ARYL PHARMTECH CO LTD (CN)

International Classes:

C07D401/12; A61K31/519; A61P29/00; A61P35/00; C07D401/14; C07D405/12; C07D405/14

Domestic Patent References:

WO2021088787A1	2021-05-14
WO2021139775A1	2021-07-15

Foreign References:

CN106220644A	2016-12-14
CN112079830A	2020-12-15

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