Title:
FUSION PROTEIN SUITABLE FOR DISSOLVING FIBRIN CLOT, AND PHARMACEUTICAL COMPOSITION CONTAINING SAID FUSION PROTEIN
Document Type and Number:
WIPO Patent Application WO/2021/200922
Kind Code:
A1
Abstract:
The present invention provides a fusion protein suitable for dissolving a fibrin clot, and a pharmaceutical composition containing said fusion protein. The present invention provides: a fusion protein of an antibody that binds to insoluble fibrin or an antigen-binding fragment thereof and a prourokinase mutant in which the amino acid sequence of plasmin in the kringle domain is modified so as to be difficult to cleave with plasmin; and a pharmaceutical composition containing said fusion protein.
Inventors:
MATSUMURA YASUHIRO (JP)
HANAOKA SHINGO (JP)
SAIJO SHINJI (JP)
HANAOKA SHINGO (JP)
SAIJO SHINJI (JP)
Application Number:
PCT/JP2021/013496
Publication Date:
October 07, 2021
Filing Date:
March 30, 2021
Export Citation:
Assignee:
NAT CANCER CT (JP)
RIN INST INC (JP)
RIN INST INC (JP)
International Classes:
A61K39/395; A61K38/49; A61P9/00; A61P9/10; C07K16/18; C07K19/00; C12N9/72; C12N15/12; C12N15/13; C12N15/58; C12N15/62
Domestic Patent References:
| WO2014133093A1 | 2014-09-04 | |||
| WO2018203517A1 | 2018-11-08 | |||
| WO2014133093A1 | 2014-09-04 | |||
| WO2018203517A1 | 2018-11-08 |
Foreign References:
| JPS62143686A | 1987-06-26 | |||
| JPS62272975A | 1987-11-27 |
Other References:
"GenBank", Database accession no. AAA61253.1
KABAT, E. A. ET AL.: "Sequences of Proteins of Immunological Interest", US DEPT. OF HEALTH AND HUMAN SERVICES
See also references of EP 4129334A4
KABAT, E. A. ET AL.: "Sequences of Proteins of Immunological Interest", US DEPT. OF HEALTH AND HUMAN SERVICES
See also references of EP 4129334A4
Attorney, Agent or Firm:
OHNO Seiji et al. (JP)
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