Title:
FXR REGULATOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/202583
Kind Code:
A1
Abstract:
Disclosed are an FXR regulator and use thereof, and specifically disclosed are a compound represented by formula I, or a stereoisomer, a prodrug, a crystal form, a pharmaceutically acceptable salt, a pharmaceutically acceptable solvate, or a pharmaceutically acceptable ester of the compound.
Inventors:
JIAO NING (CN)
DOU XIAODONG (CN)
SU LINGYU (CN)
HUO TONGYU (CN)
LIU YAMENG (CN)
DOU XIAODONG (CN)
SU LINGYU (CN)
HUO TONGYU (CN)
LIU YAMENG (CN)
Application Number:
PCT/CN2023/089016
Publication Date:
October 26, 2023
Filing Date:
April 18, 2023
Export Citation:
Assignee:
UNIV BEIJING (CN)
International Classes:
C07D307/54; A61K31/341; A61K31/343; A61K31/381; A61K31/407; A61P3/00; A61P9/00; A61P13/12; A61P29/00; A61P35/00; C07C309/76; C07D307/82; C07D407/12; C07D407/14; C07D409/12
Domestic Patent References:
| WO2018125968A1 | 2018-07-05 | |||
| WO2004046068A2 | 2004-06-03 | |||
| WO2004046162A2 | 2004-06-03 |
Other References:
DATABASE Registry CAS; 23 October 2011 (2011-10-23), ANONYMOUS : "Benzenesulfonic acid, 3- (trifluoromethyl)-, 5-(diethylamino)-2- [[(2-fluorobenzoyl)(2 -furanylmethyl)amin o]methyl]phenyl ester", XP093102450, retrieved from STN Database accession no. 1338204-92-4
DATABASE Registry CAS; 23 October 2011 (2011-10-23), ANONYMOUS : "Benzenesulfonic acid, 2- chloro-6-methyl-, 3-[[(3-fluorobenzoyl) (2-furanylmethyl)am ino]methyl]phenyl e ster", XP093102454, retrieved from STN Database accession no. 1338205-48-3
WEI CHANGYONG, BAJPAI RICHA, SHARMA HORRICK, HEITMEIER MONIQUE, JAIN ATUL D., MATULIS SHANNON M., NOOKA AJAY K., MISHRA RAMA K., H: "Development of GLUT4-selective antagonists for multiple myeloma therapy", EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, ELSEVIER, AMSTERDAM, NL, vol. 139, 1 October 2017 (2017-10-01), AMSTERDAM, NL , pages 573 - 586, XP093102251, ISSN: 0223-5234, DOI: 10.1016/j.ejmech.2017.08.029
DATABASE Registry CAS; 23 October 2011 (2011-10-23), ANONYMOUS : "Benzenesulfonic acid, 2- chloro-6-methyl-, 3-[[(3-fluorobenzoyl) (2-furanylmethyl)am ino]methyl]phenyl e ster", XP093102454, retrieved from STN Database accession no. 1338205-48-3
WEI CHANGYONG, BAJPAI RICHA, SHARMA HORRICK, HEITMEIER MONIQUE, JAIN ATUL D., MATULIS SHANNON M., NOOKA AJAY K., MISHRA RAMA K., H: "Development of GLUT4-selective antagonists for multiple myeloma therapy", EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, ELSEVIER, AMSTERDAM, NL, vol. 139, 1 October 2017 (2017-10-01), AMSTERDAM, NL , pages 573 - 586, XP093102251, ISSN: 0223-5234, DOI: 10.1016/j.ejmech.2017.08.029
Attorney, Agent or Firm:
CCPIT PATENT AND TRADEMARK LAW OFFICE (CN)
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