Title:
GALLIC ACID-L-LEUCINE CONJUGATE FOR RESOLUTION OF INFLAMMATION AND SEPSIS
Document Type and Number:
WIPO Patent Application WO/2017/066965
Kind Code:
A1
Abstract:
Compounds used for treatment of inflammation and sepsis, or pharmaceutically acceptable salts or analogs thereof are disclosed.
Inventors:
RONG JIANHUI (CA)
Application Number:
PCT/CN2015/092564
Publication Date:
April 27, 2017
Filing Date:
October 22, 2015
Export Citation:
Assignee:
UNIV HONG KONG (CN)
International Classes:
C07C233/83; A61K31/166; A61K31/216; A61P29/00
Domestic Patent References:
| WO2000059867A1 | 2000-10-12 |
Foreign References:
| KR20120053245A | 2012-05-25 | |||
| CN102924318A | 2013-02-13 |
Other References:
DATABASE REGISTRY 13 June 2012 (2012-06-13), retrieved from STN Database accession no. RN1377575-41-1
DRENNEN, BRANDON ET AL.: "Expedient access to pre-organized a-helix mimetics based on an isocinchomeronic acid core", TETRAHEDRON LETTERS, vol. 56, no. 49, 9 October 2015 (2015-10-09), pages 6819 - 6822, XP055376790, ISSN: 0040-4039
METRANO, ANTHONY J. ET AL.: "Peptide-Catalyzed Conversion of Racemic Oxazol-5(4H)-ones into Enantiomerically Enriched a-Amino Acid Derivatives", J. ORG. CHEM., vol. 79, 12 February 2014 (2014-02-12), pages 1542 - 1554, XP055376791, ISSN: 0022-3263
MALAVASIC, CRT ET AL.: "The effect of substituents on the chiral solvating properties of (S)-1, 6-dialkylpiperazine-2, 5-diones", TETRAHEDRON : ASYMMETRY, vol. 22, 31 December 2011 (2011-12-31), pages 1364 - 1371, XP028284079, ISSN: 0957-4166
DE ARAUJO, AURIGENA ANTUNES ET AL.: "Quantification of polyphenols and evaluation of antimicrobial, analgesic and anti-inflammatory activities of aqueous and acetone-water extracts of Libidibia ferrea, Parapiptadenia rigida and Psidium guajava", JOURNAL OF ETHNOPHARMACOLOGY, vol. 156, 12 August 2014 (2014-08-12), pages 88 - 96, XP029095252, ISSN: 0378-8741
MAURYA, HARIKESH ET AL.: "Prophylactic Antioxidant Potential of Gallic Acid in Murine Model of Sepsis", INTERNATIONAL JOURNAL OF INFLAMMATION, vol. 2014, 11 June 2014 (2014-06-11), pages 1 - 7, XP055376796, ISSN: 2042-0099
WEI, LAI ET AL.: "Pharmacological induction of leukotriene B4-12-hydroxydehydrogenase suppresses the oncogenic transformation of human hepatoma HepG2 cells", INTERNATIONAL JOURNAL OF ONCOLOGY, vol. 39, 31 December 2011 (2011-12-31), pages 735 - 745, XP055376801, ISSN: 1791-2423
ABAD, B. ET AL.: "The administration of lipopolysaccharide, in vivo, induces alteration in L- leucine intestinal absorption", LIFE SCIENCES, vol. 70, no. 6, 31 December 2001 (2001-12-31), pages 615 - 628, XP055376802, ISSN: 0024-3205
YANG, YING ET AL.: "L-Leucine and NO -mediated cardiovascular function", AMINO ACIDS, vol. 47, 1 January 2015 (2015-01-01), pages 435 - 447, XP035448752, ISSN: 0939-4451, DOI: doi:10.1007/s00726-014-1904-y
DRENNEN, BRANDON ET AL.: "Expedient access to pre-organized a-helix mimetics based on an isocinchomeronic acid core", TETRAHEDRON LETTERS, vol. 56, no. 49, 9 October 2015 (2015-10-09), pages 6819 - 6822, XP055376790, ISSN: 0040-4039
METRANO, ANTHONY J. ET AL.: "Peptide-Catalyzed Conversion of Racemic Oxazol-5(4H)-ones into Enantiomerically Enriched a-Amino Acid Derivatives", J. ORG. CHEM., vol. 79, 12 February 2014 (2014-02-12), pages 1542 - 1554, XP055376791, ISSN: 0022-3263
MALAVASIC, CRT ET AL.: "The effect of substituents on the chiral solvating properties of (S)-1, 6-dialkylpiperazine-2, 5-diones", TETRAHEDRON : ASYMMETRY, vol. 22, 31 December 2011 (2011-12-31), pages 1364 - 1371, XP028284079, ISSN: 0957-4166
DE ARAUJO, AURIGENA ANTUNES ET AL.: "Quantification of polyphenols and evaluation of antimicrobial, analgesic and anti-inflammatory activities of aqueous and acetone-water extracts of Libidibia ferrea, Parapiptadenia rigida and Psidium guajava", JOURNAL OF ETHNOPHARMACOLOGY, vol. 156, 12 August 2014 (2014-08-12), pages 88 - 96, XP029095252, ISSN: 0378-8741
MAURYA, HARIKESH ET AL.: "Prophylactic Antioxidant Potential of Gallic Acid in Murine Model of Sepsis", INTERNATIONAL JOURNAL OF INFLAMMATION, vol. 2014, 11 June 2014 (2014-06-11), pages 1 - 7, XP055376796, ISSN: 2042-0099
WEI, LAI ET AL.: "Pharmacological induction of leukotriene B4-12-hydroxydehydrogenase suppresses the oncogenic transformation of human hepatoma HepG2 cells", INTERNATIONAL JOURNAL OF ONCOLOGY, vol. 39, 31 December 2011 (2011-12-31), pages 735 - 745, XP055376801, ISSN: 1791-2423
ABAD, B. ET AL.: "The administration of lipopolysaccharide, in vivo, induces alteration in L- leucine intestinal absorption", LIFE SCIENCES, vol. 70, no. 6, 31 December 2001 (2001-12-31), pages 615 - 628, XP055376802, ISSN: 0024-3205
YANG, YING ET AL.: "L-Leucine and NO -mediated cardiovascular function", AMINO ACIDS, vol. 47, 1 January 2015 (2015-01-01), pages 435 - 447, XP035448752, ISSN: 0939-4451, DOI: doi:10.1007/s00726-014-1904-y
Attorney, Agent or Firm:
CHINA PATENT AGENT (H.K.) LTD. (CN)
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