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Title:
OXAZOLIDINONE COMPOUNDS AND METHODS OF USE THEREOF AS ANTIBACTERIAL AGENTS
Document Type and Number:
WIPO Patent Application WO/2017/066964
Kind Code:
A1
Abstract:
The present invention relates to oxazolidinone compounds of Formula (I): and pharmaceutically acceptable salts thereof, wherein A, E, and R1 are as defined herein. The present invention also relates to compositions which comprise at least one oxazolidinone compound of the invention. The invention also provides methods for inhibiting growth of mycobacterial cells as well as a method of treating mycobacterial infections by Mycobacterium tuberculosiscomprising administering a therapeutically effective amount of an oxazolidinone of the invention and/or apharmaceutically acceptable salt thereof, or a composition comprising such compound and/or salt.

Inventors:
YANG LIHU (US)
OLSEN DAVID B (US)
YOUNG KATHERINE (US)
SU JING (US)
MANDAL MIHIR B (US)
SUZUKI TAKAO (CN)
YOU LANYING (CN)
Application Number:
PCT/CN2015/092563
Publication Date:
April 27, 2017
Filing Date:
October 22, 2015
Export Citation:
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Assignee:
MERCK SHARP & DOHME (US)
YANG LIHU (US)
OLSEN DAVID B (US)
YOUNG KATHERINE (US)
SU JING (US)
MANDAL MIHIR B (US)
SUZUKI TAKAO (CN)
YOU LANYING (CN)
International Classes:
C07D413/10; A61K31/421; A61K31/422; A61P31/06; C07D263/20; C07D263/24; C07D413/14
Domestic Patent References:
WO2013182070A12013-12-12
WO2004014897A12004-02-19
WO2014014845A12014-01-23
WO2008106225A12008-09-04
Foreign References:
CN101993448A2011-03-30
US20130012554A12013-01-10
CN102143748A2011-08-03
Attorney, Agent or Firm:
WU, FENG & ZHANG CO. (CN)
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