Title:
GAMBOGIC ACID-LOADED MESOPOROUS NANOPARTICLE, PREPARATION METHOD THEREFOR AND USE THEREOF IN CANCER TREATMENT
Document Type and Number:
WIPO Patent Application WO/2024/007859
Kind Code:
A1
Abstract:
A gambogic acid-loaded mesoporous nanoparticle, a preparation method therefor and a use thereof in cancer treatment, relating to the technical field of medicines. The gambogic acid-loaded mesoporous nanoparticle is prepared from the following raw materials in parts by weight: 1-10 parts of a mesoporous polydopamine nanoparticle and 1-100 parts of gambogic acid. In order to enhance the treatment effect on cancers, the gambogic acid-loaded polydopamine nanoparticle is designed. The nanoparticle can exert an anti-tumor effect by means of action mechanisms such as increasing intracellular ROS levels, reducing mitochondrial membrane potential, increasing intracellular Ca2+ concentration, and inducing immunogenic cell death. The nanoparticle also has a chemotherapy effect, a photothermal conversion effect, and an immune activation effect, and thus achieves a synergistic anti-tumor effect, and therefore, important reference significance can be provided for clinical treatment of tumors such as breast cancer.
More Like This:
Inventors:
CAI LULU (CN)
LIU JIAQI (CN)
TONG RONGSHENG (CN)
TAN SUMIN (CN)
TU KERONG (CN)
LIU JIAQI (CN)
TONG RONGSHENG (CN)
TAN SUMIN (CN)
TU KERONG (CN)
Application Number:
PCT/CN2023/101630
Publication Date:
January 11, 2024
Filing Date:
June 21, 2023
Export Citation:
Assignee:
SICHUAN ACAD OF MEDICAL SCIENCESSICHUAN PROVINCIAL PEOPLES HOSPITAL (CN)
International Classes:
A61K47/69; A61K31/352; A61K41/00; A61P35/00; C08G73/06
Foreign References:
| CN115227818A | 2022-10-25 |
Other References:
SUN JIAXIN, LI YONGJING, TENG YILONG, WANG SHENG, GUO JIA, WANG CHANGCHUN: "NIR-controlled HSP90 inhibitor release from hollow mesoporous nanocarbon for synergistic tumor photothermal therapy guided by photoacoustic imaging", NANOSCALE, ROYAL SOCIETY OF CHEMISTRY, UNITED KINGDOM, vol. 12, no. 27, 16 July 2020 (2020-07-16), United Kingdom , pages 14775 - 14787, XP093125720, ISSN: 2040-3364, DOI: 10.1039/D0NR02896G
LI RUIHAO, HU XIAOCHUN, SHANG FANGJIAN, WU WENJING, ZHANG HAIJUN, WANG YIXUAN, PAN JIAWEI, SHI SHUO, DONG CHUNYAN: "Treatment of triple negative breast cancer by near infrared light triggered mild-temperature photothermal therapy combined with oxygen-independent cytotoxic free radicals", ACTA BIOMATERIALIA, ELSEVIER, AMSTERDAM, NL, vol. 148, 1 August 2022 (2022-08-01), AMSTERDAM, NL, pages 218 - 229, XP093125723, ISSN: 1742-7061, DOI: 10.1016/j.actbio.2022.06.011
JIN RONGHUA, XIE JIRONG, YANG XIAOSHAN, TIAN YU, YUAN PINGYUN, BAI YONGKANG, LIU SHIYU, CAI BOLEI, CHEN XIN: "A tumor-targeted nanoplatform with stimuli-responsive cascaded activities for multiple model tumor therapy", BIOMATERIALS SCIENCE, R S C PUBLICATIONS, GB, vol. 8, no. 7, 31 March 2020 (2020-03-31), GB , pages 1865 - 1874, XP093125725, ISSN: 2047-4830, DOI: 10.1039/C9BM01992H
TIAN BOSHI, WANG CHEN, DU YAQIAN, DONG SHUMING, FENG LILI, LIU BIN, LIU SHIKAI, DING HE, GAI SHILI, HE FEI, YANG PIAOPING: "Near InfraredâTriggered Theranostic Nanoplatform with Controlled Release of HSP90 Inhibitor for Synergistic Mild Photothermal and Enhanced Nanocatalytic Therapy with Hypoxia Relief", SMALL, WILEY, HOBOKEN, USA, vol. 18, no. 28, 1 July 2022 (2022-07-01), Hoboken, USA, XP093125726, ISSN: 1613-6810, DOI: 10.1002/smll.202200786
LI RUIHAO, HU XIAOCHUN, SHANG FANGJIAN, WU WENJING, ZHANG HAIJUN, WANG YIXUAN, PAN JIAWEI, SHI SHUO, DONG CHUNYAN: "Treatment of triple negative breast cancer by near infrared light triggered mild-temperature photothermal therapy combined with oxygen-independent cytotoxic free radicals", ACTA BIOMATERIALIA, ELSEVIER, AMSTERDAM, NL, vol. 148, 1 August 2022 (2022-08-01), AMSTERDAM, NL, pages 218 - 229, XP093125723, ISSN: 1742-7061, DOI: 10.1016/j.actbio.2022.06.011
JIN RONGHUA, XIE JIRONG, YANG XIAOSHAN, TIAN YU, YUAN PINGYUN, BAI YONGKANG, LIU SHIYU, CAI BOLEI, CHEN XIN: "A tumor-targeted nanoplatform with stimuli-responsive cascaded activities for multiple model tumor therapy", BIOMATERIALS SCIENCE, R S C PUBLICATIONS, GB, vol. 8, no. 7, 31 March 2020 (2020-03-31), GB , pages 1865 - 1874, XP093125725, ISSN: 2047-4830, DOI: 10.1039/C9BM01992H
TIAN BOSHI, WANG CHEN, DU YAQIAN, DONG SHUMING, FENG LILI, LIU BIN, LIU SHIKAI, DING HE, GAI SHILI, HE FEI, YANG PIAOPING: "Near InfraredâTriggered Theranostic Nanoplatform with Controlled Release of HSP90 Inhibitor for Synergistic Mild Photothermal and Enhanced Nanocatalytic Therapy with Hypoxia Relief", SMALL, WILEY, HOBOKEN, USA, vol. 18, no. 28, 1 July 2022 (2022-07-01), Hoboken, USA, XP093125726, ISSN: 1613-6810, DOI: 10.1002/smll.202200786
Attorney, Agent or Firm:
GAOYUNG INTELLECTUAL PROPERTY AGENCY (GENERAL PARTNERSHIP) CHENGDU (CN)
Download PDF: