Title:
生物活性分子の細胞内輸送のための機能性ナノ粒子
Document Type and Number:
Japanese Patent JP6560302
Kind Code:
B2
Abstract:
Functionalized biocompatible nanoparticles capable of penetrating through a mammalian cell membrane and delivering intracellularly a plurality of bioactive molecules for modulating a cellular function are disclosed herein The functionalized biocompatible nanoparticles comprise: a central nanoparticle ranging in size from about 5 to about 50 nm and having a polymer coating thereon, a plurality of functional groups covalently attached to the polymer coating, wherein the plurality of bioactive molecules are attached to the plurality of the functional groups, and wherein the plurality of bioactive molecules include at least a peptide and a protein, and wherein the peptide is capable of penetrating through the mammalian cell membrane and entering into the cell, and wherein the protein is capable of providing a new functionality within the cell. The protein may be a transcription factor selected from the group consisting of Oct4, Sox2, Nanog, Lin28, cMyc, and Klf4.
Inventors:
Andranic Andrew Applican
Cillian dill
Cillian dill
Application Number:
JP2017128822A
Publication Date:
August 14, 2019
Filing Date:
June 30, 2017
Export Citation:
Assignee:
Stem Genix Incorporated
International Classes:
A61K38/00; A61K47/62; A61K47/69; A61P43/00
Domestic Patent References:
| JP2014532628A | ||||
| JP2009501237A |
Foreign References:
| US20050042753 | ||||
| WO2010075575A1 |
Attorney, Agent or Firm:
Hidesaku Yamamoto
Natsuki Morishita
Takatoshi Iida
Daisuke Ishikawa
Kensaku Yamamoto
Natsuki Morishita
Takatoshi Iida
Daisuke Ishikawa
Kensaku Yamamoto