Title:
GAS CHROMATOGRAPHY-MASS SPECTROMETRY COMBINED METHOD FOR DETERMINING GENOTOXIC IMPURITY 1,3-DICHLORO-2-PROPANOL
Document Type and Number:
WIPO Patent Application WO/2023/065521
Kind Code:
A1
Abstract:
A gas chromatography-mass spectrometry combined analysis method for genotoxic impurity 1,3-dichloro-2-propanol, the method comprising the following steps: (1) carrying out pretreatment on a sample to prepare a sample solution, wherein perfluoropropionic acid is used as a derivatization reagent; and (2) measuring the sample solution using a gas chromatography-mass spectrometry combined instrument so as to determine the content of the impurity 1,3-dichloro-2-propanol in the sample. A gas chromatography-mass spectrometry analysis method for genotoxic impurity 1,3-dichloro-2-propanol. The method comprises: (1) carrying out pretreatment on a sample to prepare a sample solution, wherein perfluoropropionic acid is used as a derivatization reagent; and (2) detecting the sample solution using a gas chromatography-mass spectrometer to determine the content of the impurity 1,3-dichloro-2-propanol in the sample.
Inventors:
MA XINHUA (CN)
ZHOU BEIBEI (CN)
CHEN YANAN (CN)
JIN MEICHUN (CN)
ZHOU BEIBEI (CN)
CHEN YANAN (CN)
JIN MEICHUN (CN)
Application Number:
PCT/CN2021/139655
Publication Date:
April 27, 2023
Filing Date:
December 20, 2021
Export Citation:
Assignee:
ZHE JIANG HISUN PHARMACEUTICAL CO LTD (CN)
International Classes:
G01N30/02; C07C67/08; C07C69/63; G01N30/06; G01N30/72
Foreign References:
| CN107478739A | 2017-12-15 | |||
| CN110208431A | 2019-09-06 |
Other References:
YANG, SEHEE ET AL.: "Improvement of a GC-MS analytical method for the simultaneous detection of 3-MCPD and 1, 3-DCP in food", FOOD SCI BIOTECHNOL, vol. 27, no. 3, 17 January 2018 (2018-01-17), XP036521950, ISSN: 1226-7708, DOI: 10.1007/s10068-018-0312-6
LEGRAND, C. DOUSSET, B. TRONEL, H. BELLEVILLE, F. NABET, P.: "Measurement of plasma testosterone by gas chromatography-negative-ion mass spectrometry using pentafluoropropionic derivatives", JOURNAL OF CHROMATOGRAPHY B, ELSEVIER SCIENCE PUBLISHERS, NL, vol. 663, no. 2, 20 January 1995 (1995-01-20), NL , pages 187 - 192, XP004043675, ISSN: 0378-4347, DOI: 10.1016/0378-4347(94)00461-D
CHUNG, W.-C. HUI, K.-Y. CHENG, S.-C.: "Sensitive method for the determination of 1,3-dichloropropan-2-ol and 3-chloropropane-1,2-diol in soy sauce by capillary gas chromatography with mass spectrometric detection", JOURNAL OF CHROMATOGRAPHY A, ELSEVIER, AMSTERDAM, NL, vol. 952, no. 1-2, 5 April 2002 (2002-04-05), AMSTERDAM, NL, pages 185 - 192, XP004346358, ISSN: 0021-9673, DOI: 10.1016/S0021-9673(02)00062-6
周相娟 等 (ZHOU, XIANGJUAN ET AL.): "气相色谱－质谱法测定酱油中氯丙醇类化合物 (Determination of chloropropanols in soy sauce by GC/MS)", 中国调味品 (CHINA CONDIMENT), vol. 36, no. 5, 10 May 2011 (2011-05-10), ISSN: 1000-9973
LEGRAND, C. DOUSSET, B. TRONEL, H. BELLEVILLE, F. NABET, P.: "Measurement of plasma testosterone by gas chromatography-negative-ion mass spectrometry using pentafluoropropionic derivatives", JOURNAL OF CHROMATOGRAPHY B, ELSEVIER SCIENCE PUBLISHERS, NL, vol. 663, no. 2, 20 January 1995 (1995-01-20), NL , pages 187 - 192, XP004043675, ISSN: 0378-4347, DOI: 10.1016/0378-4347(94)00461-D
CHUNG, W.-C. HUI, K.-Y. CHENG, S.-C.: "Sensitive method for the determination of 1,3-dichloropropan-2-ol and 3-chloropropane-1,2-diol in soy sauce by capillary gas chromatography with mass spectrometric detection", JOURNAL OF CHROMATOGRAPHY A, ELSEVIER, AMSTERDAM, NL, vol. 952, no. 1-2, 5 April 2002 (2002-04-05), AMSTERDAM, NL, pages 185 - 192, XP004346358, ISSN: 0021-9673, DOI: 10.1016/S0021-9673(02)00062-6
周相娟 等 (ZHOU, XIANGJUAN ET AL.): "气相色谱－质谱法测定酱油中氯丙醇类化合物 (Determination of chloropropanols in soy sauce by GC/MS)", 中国调味品 (CHINA CONDIMENT), vol. 36, no. 5, 10 May 2011 (2011-05-10), ISSN: 1000-9973
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