Title:
GD2 LIGANDS
Document Type and Number:
WIPO Patent Application WO2004026895
Kind Code:
A3
Abstract:
The invention provides ligands of ganglioside GD2, including peptide ligands such as GGITNYNSALM; YCGGITNYNSACY; YCITNYNSCY; YCGGITNYNCY; YCTNYGVHCY; YCTNYGVCY; GGIANYNTS; YCGGIANYNCY; YCGGIANYNTSCY; and, YCIANYNTCY. GD2 ligands of the invention may for example be used to treat or diagnose diseases such as cancers in which cells express GD2, including neuroblastomas.
Inventors:
GAGNON MARTIN (CA)
SARAGOVI H URI (CA)
SARAGOVI H URI (CA)
Application Number:
PCT/CA2003/001389
Publication Date:
August 12, 2004
Filing Date:
September 19, 2003
Export Citation:
Assignee:
UNIV MCGILL (CA)
GAGNON MARTIN (CA)
SARAGOVI H URI (CA)
GAGNON MARTIN (CA)
SARAGOVI H URI (CA)
International Classes:
C07K14/78; C12N5/07; C12N5/0786; C12N5/079; C12N5/09; A61K38/00; (IPC1-7): C07K7/04; C07K7/64; A61K38/04
Foreign References:
| US5935821A | 1999-08-10 |
Other References:
CARNEMOLLA B ET AL: "HUMAN TENASCIN-R", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY OF BIOLOGICAL CHEMISTS, BALTIMORE, MD, US, vol. 271, no. 14, 5 April 1996 (1996-04-05), pages 8157 - 8160, XP000606961, ISSN: 0021-9258
PROBSTMEIER RAINER ET AL: "Tenascin-C inhibits beta1 integrin-dependent cell adhesion and neurite outgrowth on fibronectin by a disialoganglioside-mediated signaling mechanism", GLYCOBIOLOGY, vol. 9, no. 2, February 1999 (1999-02-01), pages 101 - 104, XP009023657, ISSN: 0959-6658
TSAO CHUN-YEN ET AL: "Identification of GD2 ganglioside peptide mimics by using phage display peptide libraries", PROCEEDINGS OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH ANNUAL, vol. 43, March 2002 (2002-03-01), 93rd Annual Meeting of the American Association for Cancer Research;San Francisco, California, USA; April 06-10, 2002, March, 2002, pages 280, XP001157107, ISSN: 0197-016X
CHEUNG NAI-KONG V ET AL: "Disialoganglioside G-D2 anti-idiotypic monoclonal antibodies", INTERNATIONAL JOURNAL OF CANCER, vol. 54, no. 3, 1993, pages 499 - 505, XP009023655, ISSN: 0020-7136
TUR MEHMET KEMAL ET AL: "An anti-GD2 single chain Fv selected by phage display and fused to Pseudomonas exotoxin A develops specific cytotoxic activity against neuroblastoma derived cell lines", INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, vol. 8, no. 5, November 2001 (2001-11-01), pages 579 - 584, XP009023656, ISSN: 1107-3756
SARAGOVI H URI ET AL: "Cell surface GD2 gangliosides act as genuine receptors: ligands activate p56Lck signal transduction and regulate tumorigenesis in vitro and in vivo.", FASEB JOURNAL, vol. 17, no. 4-5, March 2003 (2003-03-01), FASEB Meeting on Experimental Biology: Translating the Genome;San Diego, CA, USA; April 11-15, 2003, pages Abstract No. 363.4, XP009023658, ISSN: 0892-6638 (ISSN print)
PROBSTMEIER RAINER ET AL: "Tenascin-C inhibits beta1 integrin-dependent cell adhesion and neurite outgrowth on fibronectin by a disialoganglioside-mediated signaling mechanism", GLYCOBIOLOGY, vol. 9, no. 2, February 1999 (1999-02-01), pages 101 - 104, XP009023657, ISSN: 0959-6658
TSAO CHUN-YEN ET AL: "Identification of GD2 ganglioside peptide mimics by using phage display peptide libraries", PROCEEDINGS OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH ANNUAL, vol. 43, March 2002 (2002-03-01), 93rd Annual Meeting of the American Association for Cancer Research;San Francisco, California, USA; April 06-10, 2002, March, 2002, pages 280, XP001157107, ISSN: 0197-016X
CHEUNG NAI-KONG V ET AL: "Disialoganglioside G-D2 anti-idiotypic monoclonal antibodies", INTERNATIONAL JOURNAL OF CANCER, vol. 54, no. 3, 1993, pages 499 - 505, XP009023655, ISSN: 0020-7136
TUR MEHMET KEMAL ET AL: "An anti-GD2 single chain Fv selected by phage display and fused to Pseudomonas exotoxin A develops specific cytotoxic activity against neuroblastoma derived cell lines", INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, vol. 8, no. 5, November 2001 (2001-11-01), pages 579 - 584, XP009023656, ISSN: 1107-3756
SARAGOVI H URI ET AL: "Cell surface GD2 gangliosides act as genuine receptors: ligands activate p56Lck signal transduction and regulate tumorigenesis in vitro and in vivo.", FASEB JOURNAL, vol. 17, no. 4-5, March 2003 (2003-03-01), FASEB Meeting on Experimental Biology: Translating the Genome;San Diego, CA, USA; April 11-15, 2003, pages Abstract No. 363.4, XP009023658, ISSN: 0892-6638 (ISSN print)
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