Title:
SYNTHESIS AND CHARACTERIZATION OF NOVEL SYSTEMS FOR GUIDANCE AND VECTORIZATION OF COMPOUNDS HAVING A THERAPEUTIC ACTIVITY
Document Type and Number:
WIPO Patent Application WO2004026894
Kind Code:
A3
Abstract:
The invention relates to a method for preparing a grafted homodetic cyclopeptde forming a frame defining two surfaces, one surface being known as the upper surface and the other surface being known as the lower surface, both surfaces being grafted, characterized in the a linear peptide is synthesized, said synthesis being carried out on modified amino acids or not, some of which includeorthogonal protector groups, intramolecular cylization of the protected linear peptide thus obtained is performed, all or part of the orthogonal protector groups are substituted by a protected precursor, and at least one molecule of therapeutic interest is grafted on one and/or the other surface of the frame by means of an oxime link.
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Inventors:
DUMY PASCAL (FR)
FAVROT MARIE-CHRISTINE (FR)
BOTURYN DIDIER (FR)
COLL JEAN-LUC (FR)
FAVROT MARIE-CHRISTINE (FR)
BOTURYN DIDIER (FR)
COLL JEAN-LUC (FR)
Application Number:
PCT/FR2003/002773
Publication Date:
June 24, 2004
Filing Date:
September 19, 2003
Export Citation:
Assignee:
CENTRE NAT RECH SCIENT (FR)
UNIV JOSEPH FOURIER (FR)
INST NAT SANTE RECH MED (FR)
DUMY PASCAL (FR)
FAVROT MARIE-CHRISTINE (FR)
BOTURYN DIDIER (FR)
COLL JEAN-LUC (FR)
UNIV JOSEPH FOURIER (FR)
INST NAT SANTE RECH MED (FR)
DUMY PASCAL (FR)
FAVROT MARIE-CHRISTINE (FR)
BOTURYN DIDIER (FR)
COLL JEAN-LUC (FR)
International Classes:
A61P35/00; C07K7/64; C07K9/00; A61K38/00; (IPC1-7): C07K9/00; A61K38/04; G01N33/68; C07K7/64
Other References:
P DUMY ET AL.: "A convenient synthesis of cyclic peptides as regioselectively addressable functionalized templates (RAFT)", TETRAHEDRON LETTERS., vol. 38, no. 8, 1995, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM., NL, pages 1255 - 1258, XP002251829, ISSN: 0040-4039
F PERI ET AL.: "Chemo- and stereoselective glycosylation of hydroxylamino derivatives: a versatile approach to glycoconjugates", TETRAHEDRON., vol. 54, 1998, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM., NL, pages 12269 - 12278, XP002251830, ISSN: 0040-4020
O RENAUDET & P DUMY: "Expedient synthesis of aminooxylated-carbohydrates for chemoselective access of glycoconjugates", TETRAHEDRON LETTERS., vol. 42, 2001, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM., NL, pages 7575 - 7578, XP002251831, ISSN: 0040-4039
O RENAUDET & P DUMY: "Chemoselectively template-assembled glycoconjugates as mimics for multivalent presentation of carbohydrates", ORGANIC LETTERS., vol. 5, no. 3, 2003, ACS, WASHINGTON, DC., US, pages 243 - 246, XP002251832, ISSN: 1523-7060
D FORGET ET AL.: "3-oligonucleotides conjugation via chemoselective oxime bond formation", TETRAHEDRON LETTERS., vol. 42, no. 52, 2001, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM., NL, pages 9171 - 9174, XP004328105, ISSN: 0040-4039
F PERI ET AL.: "Chemo- and stereoselective glycosylation of hydroxylamino derivatives: a versatile approach to glycoconjugates", TETRAHEDRON., vol. 54, 1998, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM., NL, pages 12269 - 12278, XP002251830, ISSN: 0040-4020
O RENAUDET & P DUMY: "Expedient synthesis of aminooxylated-carbohydrates for chemoselective access of glycoconjugates", TETRAHEDRON LETTERS., vol. 42, 2001, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM., NL, pages 7575 - 7578, XP002251831, ISSN: 0040-4039
O RENAUDET & P DUMY: "Chemoselectively template-assembled glycoconjugates as mimics for multivalent presentation of carbohydrates", ORGANIC LETTERS., vol. 5, no. 3, 2003, ACS, WASHINGTON, DC., US, pages 243 - 246, XP002251832, ISSN: 1523-7060
D FORGET ET AL.: "3-oligonucleotides conjugation via chemoselective oxime bond formation", TETRAHEDRON LETTERS., vol. 42, no. 52, 2001, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM., NL, pages 9171 - 9174, XP004328105, ISSN: 0040-4039
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