Title:
GEL COMPOSITION AND TRANS-SCROTAL APPLICATION OF A COMPOSITION FOR THE TREATMENT OF HYPOGONADISM
Document Type and Number:
WIPO Patent Application WO2002051421
Kind Code:
A3
Abstract:
The invention relates to an alcohol-based gel composition, comprising at least one androgenic steroid and at least one C3-C4 diol as absorption improver and the use of a composition, comprising at least one androgenic steroid, on the scrotum, for the treatment and/or prophylaxis of hypogonadism.
Inventors:
SCHULZE BERND (DE)
NIESCHLAG EBERHARD (DE)
NIESCHLAG EBERHARD (DE)
Application Number:
PCT/EP2001/015123
Publication Date:
November 07, 2002
Filing Date:
December 20, 2001
Export Citation:
Assignee:
AUGUST WOLFF GMBH & CO DR (DE)
SCHULZE BERND (DE)
NIESCHLAG EBERHARD (DE)
SCHULZE BERND (DE)
NIESCHLAG EBERHARD (DE)
International Classes:
A61K9/00; A61K31/568; A61K47/10; A61P15/08; (IPC1-7): A61K31/568; A61K47/10; A61P15/08
Domestic Patent References:
| WO1999024041A1 | 1999-05-20 | |||
| WO1997041865A1 | 1997-11-13 | |||
| WO1997043989A1 | 1997-11-27 | |||
| WO2002011768A1 | 2002-02-14 |
Foreign References:
| US5776923A | 1998-07-07 | |||
| DE19803193C1 | 1999-07-15 | |||
| US5968919A | 1999-10-19 | |||
| US4867982A | 1989-09-19 | |||
| EP0043738A2 | 1982-01-13 |
Other References:
FINDLAY J C ET AL: "TREATMENT OF PRIMARY HYPOGONADISM IN MEN BY THE TRANSDERMAL ADMINISTRATION OF TESTOSTERONE", JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, vol. 68, no. 2, 1989, pages 369 - 373, XP001088685, ISSN: 0021-972X
LIN S S ET AL: "Transdermal testosterone delivery: Comparison between scrotal and nonscrotal delivery systems", PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY, (AUG 1999) VOL. 4, NO. 3, PP. 405-414. PUBLISHER: MARCEL DEKKER INC, 270 MADISON AVE, NEW YORK, NY 10016. ISSN: 1083-7450., RUTGERS STATE UNIV, COLL PHARM, CONTROLLED DRUG DELIVERY RES CTR, POB 10406, NEW BRUNSWICK, NJ 08906 (Reprint);RUTGERS STATE UNIV, COLL PHARM, CONTROLLED DRUG DELIVERY RES CTR, NEW BRUNSWICK, NJ 08906, XP001084425
"Dictonnaire Vidal", 1982, XP002205868
KIM E D ET AL: "Papaverine topical gel for treatment of erectile dysfunction.", THE JOURNAL OF UROLOGY. UNITED STATES FEB 1995, vol. 153, no. 2, February 1995 (1995-02-01), pages 361 - 365, XP001084767, ISSN: 0022-5347
ODAME I ET AL: "Early diagnosis and management of 5 alpha-reductase deficiency.", ARCHIVES OF DISEASE IN CHILDHOOD. ENGLAND JUN 1992, vol. 67, no. 6, June 1992 (1992-06-01), pages 720 - 723, XP001088867, ISSN: 1468-2044
LIN S S ET AL: "Transdermal testosterone delivery: Comparison between scrotal and nonscrotal delivery systems", PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY, (AUG 1999) VOL. 4, NO. 3, PP. 405-414. PUBLISHER: MARCEL DEKKER INC, 270 MADISON AVE, NEW YORK, NY 10016. ISSN: 1083-7450., RUTGERS STATE UNIV, COLL PHARM, CONTROLLED DRUG DELIVERY RES CTR, POB 10406, NEW BRUNSWICK, NJ 08906 (Reprint);RUTGERS STATE UNIV, COLL PHARM, CONTROLLED DRUG DELIVERY RES CTR, NEW BRUNSWICK, NJ 08906, XP001084425
"Dictonnaire Vidal", 1982, XP002205868
KIM E D ET AL: "Papaverine topical gel for treatment of erectile dysfunction.", THE JOURNAL OF UROLOGY. UNITED STATES FEB 1995, vol. 153, no. 2, February 1995 (1995-02-01), pages 361 - 365, XP001084767, ISSN: 0022-5347
ODAME I ET AL: "Early diagnosis and management of 5 alpha-reductase deficiency.", ARCHIVES OF DISEASE IN CHILDHOOD. ENGLAND JUN 1992, vol. 67, no. 6, June 1992 (1992-06-01), pages 720 - 723, XP001088867, ISSN: 1468-2044
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