Title:
PREVENTIVES/ERMEDIES FOR INFLAMMATORY AIRWAY DISEASES
Document Type and Number:
WIPO Patent Application WO/2002/051422
Kind Code:
A1
Abstract:
Preventives and/or remedies for inflammatory airway diseases which contain as the active ingredient steroid derivatives represented by the following general formula (1): (1) wherein R represents hydrogen, halogeno, hydroxy or -OCOR?1¿ (wherein R?1¿ represents linear or branched alkyl, cycloalkyl or aryl optionally substituted by halogeno or cycloalkyl). These compounds can continuously suppress airway inflammation and airway hyperreaction and show a high site-selectivity and little systemic effect when applied directly to the airway. Owing to these characteristics, these compounds are extremely useful in clinical medicine as highly safe preventives and/or remedies for inflammatory airway diseases which can be administered over a long time.
Inventors:
KOMOTO TERUO (JP)
MIZUNO HIROYUKI (JP)
TAKAHASHI YOSHINORI (JP)
TAKAHASHI KOICHI (JP)
SATO SUSUMU (JP)
MIZUNO HIROYUKI (JP)
TAKAHASHI YOSHINORI (JP)
TAKAHASHI KOICHI (JP)
SATO SUSUMU (JP)
Application Number:
PCT/JP2001/011264
Publication Date:
July 04, 2002
Filing Date:
December 21, 2001
Export Citation:
Assignee:
SSP CO LTD (JP)
KOMOTO TERUO (JP)
MIZUNO HIROYUKI (JP)
TAKAHASHI YOSHINORI (JP)
TAKAHASHI KOICHI (JP)
SATO SUSUMU (JP)
KOMOTO TERUO (JP)
MIZUNO HIROYUKI (JP)
TAKAHASHI YOSHINORI (JP)
TAKAHASHI KOICHI (JP)
SATO SUSUMU (JP)
International Classes:
A61K31/57; A61K31/573; A61P11/06; A61P27/16; C07J5/00; C07J7/00; (IPC1-7): A61K31/57; A61K31/573; A61P11/06; A61P27/16
Domestic Patent References:
| WO1995020393A1 | 1995-08-03 |
Foreign References:
| EP0393658A2 | 1990-10-24 |
Other References:
UENO H. ET AL., J. MED. CHEM., vol. 34, no. 8, 1991, pages 2468 - 2473, XP002086576
See also references of EP 1344526A4
See also references of EP 1344526A4
Attorney, Agent or Firm:
Aruga, Mitsuyuki (3-6 NIHONBASHININGYOCHO 1-CHOME CHUO-KU, Tokyo, JP)
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