Title:
GENE DELIVERY SYSTEM TARGETING RETINA AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2024/021429
Kind Code:
A1
Abstract:
The present invention belongs to the field of biotechnology, and particularly relates to a gene delivery system targeting retina and use thereof. The gene delivery system targeting retina comprises an adeno-associated virus vector rAAV11. The adeno-associated virus vector rAAV11 comprises a gene encoding a marker protein and a promoter and targets retinal cells. Compared with other vectors, the rAAV11 vector can efficiently and specifically deliver genes to retinal bipolar cells.
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Inventors:
LIN KUNZHANG (CN)
HAN ZENGPENG (CN)
LUO NENGSONG (CN)
XU FUQIANG (CN)
HAN ZENGPENG (CN)
LUO NENGSONG (CN)
XU FUQIANG (CN)
Application Number:
PCT/CN2022/137380
Publication Date:
February 01, 2024
Filing Date:
December 07, 2022
Export Citation:
Assignee:
SHENZHEN INST ADV TECH (CN)
International Classes:
C12N15/864; A61K48/00; A61P9/10; A61P27/02; C12N15/53; C12N15/65
Foreign References:
| CN115323001A | 2022-11-11 | |||
| US20220226507A1 | 2022-07-21 | |||
| CN114728132A | 2022-07-08 | |||
| US20120093772A1 | 2012-04-19 |
Other References:
HAN ZENGPENG, LUO NENGSONG, KOU JIAXIN, LI LEI, MA WENYU, PENG SIQI, XU ZIHONG, ZHANG WEN, QIU YUXIANG, WU YANG, WANG JIE, YE CHAO: "AAV11 permits efficient retrograde targeting of projection neurons", BIORXIV, 13 January 2022 (2022-01-13), XP093134147, DOI: 10.1101/2022.01.13.476170
Attorney, Agent or Firm:
BEIJING ZHONG XUN TONG DA INTELLECTUAL PROPERTY AGENCY CO., LTD. (CN)
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