Title:
GENETICALLY ENCODED YEATS DOMAIN PROBE AND APPLICATIONS THEREOF
Document Type and Number:
WIPO Patent Application WO/2022/022511
Kind Code:
A1
Abstract:
Provided is a product, composition that contains genetically encoded YEATS domain probe. Provided is a method of making the genetically encoded YEATS domain probes. Also provided are methods of modulating YEATS domain proteins using the genetically encoded probes.
Inventors:
LI XIANG DAVID (CN)
LI XIN (CN)
TIAN GAOFEI (CN)
LI XIN (CN)
TIAN GAOFEI (CN)
Application Number:
PCT/CN2021/108680
Publication Date:
February 03, 2022
Filing Date:
July 27, 2021
Export Citation:
Assignee:
UNIV HONG KONG (CN)
International Classes:
C07K7/06; C07K19/00; C12N5/10; C12N15/63; C12P21/02
Domestic Patent References:
| WO2019101195A1 | 2019-05-31 |
Other References:
WAN WEI; THARP JEFFERY M.; LIU WENSHE R.: "Pyrrolysyl-tRNA synthetase: An ordinary enzyme but an outstanding genetic code expansion tool", BIOCHIMICA ET BIOPHYSICA ACTA (BBA) - PROTEINS & PROTEOMICS, vol. 1844, no. 6, 12 March 2014 (2014-03-12), Netherlands , pages 1059 - 1070, XP028638306, ISSN: 1570-9639, DOI: 10.1016/j.bbapap.2014.03.002
LI XIN; LI XIAO-MENG; JIANG YIXIANG; LIU ZHENG; CUI YIWEN; FUNG KA YI; BEELEN STAN H. VAN DER; TIAN GAOFEI; WAN LILING; SHI XIAOBI: "Structure-guided development of YEATS domain inhibitors by targeting π-π-π stacking", NATURE CHEMICAL BIOLOGY, vol. 14, no. 12, 29 October 2018 (2018-10-29), New York, pages 1140 - 1149, XP036637456, ISSN: 1552-4450, DOI: 10.1038/s41589-018-0144-y
ANAËLLE DUMAS; LUKAS LERCHER; CHRISTOPHER D SPICER; BENJAMIN G DAVIS: "Designing logical codon reassignment - Expanding the chemistry in biology", CHEMICAL SCIENCE, vol. 6, no. 1, 1 January 2015 (2015-01-01), United Kingdom , pages 50 - 69, XP055490374, ISSN: 2041-6520, DOI: 10.1039/C4SC01534G
LI YUANYUAN; SABARI BENJAMIN R; PANCHENKO TATYANA; WEN HONG; ZHAO DAN; GUAN HAIPENG; WAN LILING; HUANG HE; TANG ZHANYUN; ZHAO YING: "Molecular Coupling of Histone Crotonylation and Active Transcription by AF9 YEATS Domain", MOLECULAR CELL, vol. 62, no. 2, 21 April 2016 (2016-04-21), AMSTERDAM, NL, pages 181 - 193, XP029518381, ISSN: 1097-2765, DOI: 10.1016/j.molcel.2016.03.028
ZHAO DAN; LI YUANYUAN; XIONG XIAOZHE; CHEN ZHONGLEI; LI HAITAO: "YEATS Domain—A Histone Acylation Reader in Health and Disease", JOURNAL OF MOLECULAR BIOLOGY, vol. 429, no. 13, 11 March 2017 (2017-03-11), United Kingdom , pages 1994 - 2002, XP085073533, ISSN: 0022-2836, DOI: 10.1016/j.jmb.2017.03.010
LI XIN; LI XIAO-MENG; JIANG YIXIANG; LIU ZHENG; CUI YIWEN; FUNG KA YI; BEELEN STAN H. VAN DER; TIAN GAOFEI; WAN LILING; SHI XIAOBI: "Structure-guided development of YEATS domain inhibitors by targeting π-π-π stacking", NATURE CHEMICAL BIOLOGY, vol. 14, no. 12, 29 October 2018 (2018-10-29), New York, pages 1140 - 1149, XP036637456, ISSN: 1552-4450, DOI: 10.1038/s41589-018-0144-y
ANAËLLE DUMAS; LUKAS LERCHER; CHRISTOPHER D SPICER; BENJAMIN G DAVIS: "Designing logical codon reassignment - Expanding the chemistry in biology", CHEMICAL SCIENCE, vol. 6, no. 1, 1 January 2015 (2015-01-01), United Kingdom , pages 50 - 69, XP055490374, ISSN: 2041-6520, DOI: 10.1039/C4SC01534G
LI YUANYUAN; SABARI BENJAMIN R; PANCHENKO TATYANA; WEN HONG; ZHAO DAN; GUAN HAIPENG; WAN LILING; HUANG HE; TANG ZHANYUN; ZHAO YING: "Molecular Coupling of Histone Crotonylation and Active Transcription by AF9 YEATS Domain", MOLECULAR CELL, vol. 62, no. 2, 21 April 2016 (2016-04-21), AMSTERDAM, NL, pages 181 - 193, XP029518381, ISSN: 1097-2765, DOI: 10.1016/j.molcel.2016.03.028
ZHAO DAN; LI YUANYUAN; XIONG XIAOZHE; CHEN ZHONGLEI; LI HAITAO: "YEATS Domain—A Histone Acylation Reader in Health and Disease", JOURNAL OF MOLECULAR BIOLOGY, vol. 429, no. 13, 11 March 2017 (2017-03-11), United Kingdom , pages 1994 - 2002, XP085073533, ISSN: 0022-2836, DOI: 10.1016/j.jmb.2017.03.010
Attorney, Agent or Firm:
LIU, SHEN & ASSOCIATES (CN)
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