Title:
GLP-1 PEPTIDE HAVING SUGAR CHAIN ATTACHED THERETO
Document Type and Number:
WIPO Patent Application WO/2008/155900
Kind Code:
A1
Abstract:
Disclosed is a GLP-1 peptide having a sugar chain attached thereto, which has
a longer blood half-life compared with GLP-1 and preferably also has a high blood
glucose level lowering activity. Specifically disclosed is a GLP-1 peptide
having a sugar chain attached thereto and having a GLP-1 activity, which is produced
by substituting at least one amino acid residue in any one of the following components
(a) to (c) by an amino acid residue having a sugar chain attached thereto: (a) GLP-1;
(b) a peptide having the deletion, substitution or addition of one or several
amino acid residues in GLP-1; and (c) an analogue of GLP-1.
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Inventors:
KAJIHARA YASUHIRO (JP)
TSUJI TAKASHI (JP)
SAKAMOTO IZUMI (JP)
NAMBU YURI (JP)
FUKAE KAZUHIRO (JP)
TEZUKA KATSUNARI (JP)
ASAI HIROAKI (JP)
TSUJI TAKASHI (JP)
SAKAMOTO IZUMI (JP)
NAMBU YURI (JP)
FUKAE KAZUHIRO (JP)
TEZUKA KATSUNARI (JP)
ASAI HIROAKI (JP)
Application Number:
PCT/JP2008/001554
Publication Date:
December 24, 2008
Filing Date:
June 17, 2008
Export Citation:
Assignee:
OTSUKA CHEMICAL CO LTD (JP)
UNIV YOKOHAMA CITY (JP)
KAJIHARA YASUHIRO (JP)
TSUJI TAKASHI (JP)
SAKAMOTO IZUMI (JP)
NAMBU YURI (JP)
FUKAE KAZUHIRO (JP)
TEZUKA KATSUNARI (JP)
ASAI HIROAKI (JP)
UNIV YOKOHAMA CITY (JP)
KAJIHARA YASUHIRO (JP)
TSUJI TAKASHI (JP)
SAKAMOTO IZUMI (JP)
NAMBU YURI (JP)
FUKAE KAZUHIRO (JP)
TEZUKA KATSUNARI (JP)
ASAI HIROAKI (JP)
International Classes:
A61K38/00; C07K14/605; A61P3/10
Domestic Patent References:
| WO2006010143A2 | 2006-01-26 | |||
| WO2004005330A1 | 2004-01-15 | |||
| WO2005010053A1 | 2005-02-03 |
Other References:
MEURER J.A. ET AL.: "Properties of native and in vitro glycosylated forms of the glucagon-like peptide-1 receptor antagonist exendin (9-39)", METABOLISM, vol. 48, no. 6, 1999, pages 716 - 724, XP004538345
Attorney, Agent or Firm:
NANJO, Masahiro et al. (23rd Floor Roppongi Hills Mori Tower,6-10-1, Roppong, Minato-ku Tokyo 23, JP)
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