Title:
GLUCOSE DERIVATIVES AND ANTICANCER AGENT USING SAME
Document Type and Number:
WIPO Patent Application WO/2023/058608
Kind Code:
A1
Abstract:
Provided are novel glucose derivatives and an anticancer agent using the same. The glucose derivatives according to the present invention consist of an L-glucose derivative represented by general formula (1) and a D-glucose derivative represented by general formula (2). In formula (1): XL2 represents an -SAuRL2 group; and XL1, XL3, XL4 and XL5 independently represent an -ORL1 group, an -NH2 group or a fluorine atom. RL2 represents a ligand, and RL1 represents a hydrogen atom or an organic group. In formula (2): XD2 represents an -SAuRD2 group; and XD1, XD3, XD4 and XD5 independently represent an -ORD1 group, an -NH2 group or a fluorine atom. RD2 represents a ligand, and RD1 represents a hydrogen atom or an organic group. The anticancer agent according to the present invention comprises at least one of the aforesaid glucose derivatives.
Inventors:
YAMAGUCHI EIICHI (JP)
YAMADA KATSUYA (JP)
ONO KOKI (JP)
TANAKA KOTA (JP)
IIJIMA HIDEKI (JP)
YAMADA KATSUYA (JP)
ONO KOKI (JP)
TANAKA KOTA (JP)
IIJIMA HIDEKI (JP)
Application Number:
PCT/JP2022/037001
Publication Date:
April 13, 2023
Filing Date:
October 03, 2022
Export Citation:
Assignee:
ORBIO CORP (JP)
International Classes:
C07H23/00; A61K31/7135; A61K33/242; A61P35/00
Domestic Patent References:
| WO2012133688A1 | 2012-10-04 | |||
| WO2021201109A1 | 2021-10-07 |
Foreign References:
| US5624908A | 1997-04-29 | |||
| JP2011236140A | 2011-11-24 | |||
| JP2021013857W | 2021-03-31 | |||
| US10001487B2 | 2018-06-19 | |||
| US10509041B2 | 2019-12-17 | |||
| EP3130596B1 | 2021-01-20 | |||
| JP6566348B2 | 2019-08-28 |
Other References:
WERNER FUDICKAR; PRASHANT PAVASHE; TORSTEN LINKER: "Thiocarbohydrates on Gold Nanoparticles: Strong Influence of Stereocenters on Binding Affinity and Interparticle Forces", CHEMISTRY - A EUROPEAN JOURNAL, JOHN WILEY & SONS, INC, DE, vol. 23, no. 36, 7 June 2017 (2017-06-07), DE, pages 8685 - 8693, XP071843632, ISSN: 0947-6539, DOI: 10.1002/chem.201700846
ONO K ET AL., CANCERS, vol. 12, 2020, pages 850
MIYAZAKI J ET AL., ENDOCRINOLOGY, vol. 127, 1990, pages 126 - 132
J. AM. CHEM. SOC., vol. 132, 2010, pages 7405 - 7417
J. ORG. CHEM., vol. 82, 2017, pages 12613 - 12623
YAMADA, K. ET AL., J. BIOL. CHEM., vol. 275, 2000, pages 22278 - 83
YAMADA, K, NATURE PROTOCOLS, vol. 2, 2007, pages 753 - 62
SASAKI, A. ET AL., HUMAN CELL, vol. 29, 2016, pages 37 - 45
HUMAN CELL, vol. 34, 2021, pages 634 - 643
ORG. LETT., vol. 18, 2016, pages 1338 - 1341
HUMAN, CELL, vol. 29, 2016, pages 37 - 45
ONODERA, T. ET AL., J. BIOL. CHEM., vol. 295, 2020, pages 16678 - 16690
ACS MED. CHEM. LETT., vol. 8, 2017, pages 997 - 1001
ONO K ET AL., CANCERS, vol. 12, 2020, pages 850
MIYAZAKI J ET AL., ENDOCRINOLOGY, vol. 127, 1990, pages 126 - 132
J. AM. CHEM. SOC., vol. 132, 2010, pages 7405 - 7417
J. ORG. CHEM., vol. 82, 2017, pages 12613 - 12623
YAMADA, K. ET AL., J. BIOL. CHEM., vol. 275, 2000, pages 22278 - 83
YAMADA, K, NATURE PROTOCOLS, vol. 2, 2007, pages 753 - 62
SASAKI, A. ET AL., HUMAN CELL, vol. 29, 2016, pages 37 - 45
HUMAN CELL, vol. 34, 2021, pages 634 - 643
ORG. LETT., vol. 18, 2016, pages 1338 - 1341
HUMAN, CELL, vol. 29, 2016, pages 37 - 45
ONODERA, T. ET AL., J. BIOL. CHEM., vol. 295, 2020, pages 16678 - 16690
ACS MED. CHEM. LETT., vol. 8, 2017, pages 997 - 1001
Attorney, Agent or Firm:
SHOBAYASHI Masayuki et al. (JP)
Download PDF: