Title:
GLUTAMATE TRANSPORT MODULATORY COMPOUNDS AND METHODS
Document Type and Number:
WIPO Patent Application WO2004076675
Kind Code:
A3
Abstract:
Described herein are methods of modulating excitatory amino acid transporter (EAAT) protein expression, methods of treating disease and disease symptoms, methods of identifying compounds that modulate EAAT protein expression, and compounds useful for modulating EAAT protein expression and treating disease and disease symptoms.
Inventors:
ROTHSTEIN JEFFREY D (US)
Application Number:
PCT/US2004/005698
Publication Date:
March 17, 2005
Filing Date:
February 25, 2004
Export Citation:
Assignee:
UNIV JOHNS HOPKINS (US)
ROTHSTEIN JEFFREY D (US)
ROTHSTEIN JEFFREY D (US)
International Classes:
C07K14/47; C12N15/00; C12Q1/68; C12P; (IPC1-7): C12N15/00; C12Q1/68
Other References:
ROTHSTEIN ET AL.: "Chronic inhibition of glutamate uptake produces a model of slow neurotoxicity", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, USA, vol. 90, July 1993 (1993-07-01), pages 6591 - 6595, XP000907207
ROWLAND ET AL.: "Medical prograss: Amyotrophic lateral sclerosis", THE NEW ENGLAND JOURNAL OF MEDICINE, vol. 344, no. 22, 31 May 2001 (2001-05-31), pages 1688 - 1700, XP008041193
ROWLAND ET AL.: "Medical prograss: Amyotrophic lateral sclerosis", THE NEW ENGLAND JOURNAL OF MEDICINE, vol. 344, no. 22, 31 May 2001 (2001-05-31), pages 1688 - 1700, XP008041193
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