Title:
GLYCOSIDES AND ORTHOESTER GLYCOSIDES OF GLUCOCORTICOIDS AND USES THEREOF
Document Type and Number:
WIPO Patent Application WO2001051057
Kind Code:
A3
Abstract:
Serum levels of therapeutically useful glucocorticosteroids are substantially increased by oral administration of the corresponding glycoside or orthoester glycoside.
Inventors:
HOLICK MICHAEL FRANCIS (US)
RAMANATHAN HALASYA (US)
RAMANATHAN HALASYA (US)
Application Number:
PCT/GB2001/000146
Publication Date:
March 21, 2002
Filing Date:
January 15, 2001
Export Citation:
Assignee:
STRAKAN GROUP PLC (GB)
HOLICK MICHAEL FRANCIS (US)
RAMANATHAN HALASYA (US)
HOLICK MICHAEL FRANCIS (US)
RAMANATHAN HALASYA (US)
International Classes:
A61K31/704; A61P29/00; C07H15/18; (IPC1-7): A61K31/58; A61P29/00; A61K31/70; C07J17/00
Domestic Patent References:
| WO1993022334A1 | 1993-11-11 | |||
| WO1993021198A1 | 1993-10-28 | |||
| WO1994015947A1 | 1994-07-21 |
Foreign References:
| EP0123485A1 | 1984-10-31 | |||
| US3427300A | 1969-02-11 | |||
| EP0721956A1 | 1996-07-17 | |||
| US3733318A | 1973-05-15 | |||
| GB1015396A | 1965-12-31 |
Other References:
CHEMICAL ABSTRACTS, vol. 125, no. 18, 28 October 1996, Columbus, Ohio, US; abstract no. 230346, NOLEN, H. III ET AL: "Glucuronide prodrugs for colonic delivery: steady-state kinetics in conventional and colitic rats" XP002183495
CHEMICAL ABSTRACTS, vol. 123, no. 13, 25 September 1995, Columbus, Ohio, US; abstract no. 161106, FEDORAK, RICHARD N. ET AL: "A novel colon-specific steroid prodrug enhances sodium chloride absorptio in rat colitis" XP002183496
CHEMICAL ABSTRACTS, vol. 118, no. 24, 14 June 1993, Columbus, Ohio, US; abstract no. 240666, FRIEND, D. ET AL: "Relative antiinflammatory effect of oral dexamethasone-.beta.-D-glucoside and dexamethasone in experimental IBD" XP002183497
CHEMICAL ABSTRACTS, vol. 115, no. 5, 5 August 1991, Columbus, Ohio, US; abstract no. 42233, FRIEND, D. R. ET AL: "Relative anti-inflammatory effect of oral dexamethasone-.beta.-D-glucosid and dexamethasone in experimental inflammatory bowel disease in guinea pigs" XP002183498
CHEMICAL ABSTRACTS, vol. 96, no. 17, 26 April 1982, Columbus, Ohio, US; abstract no. 136023, ALTHAUS, ZELDA R. ET AL: "Separation of some natural and synthetic corticosteroids in biological fluids and tissues by high-performance liquid chromatography" XP002183499
CHEMICAL ABSTRACTS, vol. 71, no. 3, 21 July 1969, Columbus, Ohio, US; abstract no. 13321, MATTOX, VERNON R. ET AL: "Synthesis of C-21 glucosiduronates of cortisone and related corticosteroids" XP002183500
CHEMICAL ABSTRACTS, vol. 102, no. 4, 28 January 1985, Columbus, Ohio, US; abstract no. 32032, FRIEND, DAVID R. ET AL: "Drug glycosides: potential prodrugs for colon-specific drug delivery" XP002183501
CHEMICAL ABSTRACTS, vol. 100, no. 10, 5 March 1984, Columbus, Ohio, US; abstract no. 73892, FRIEND, DAVID R. ET AL: "A colon-specific drug-delivery system based on drug glycosides and the glycosidases of colonic bacteria" XP002183502
CHEMICAL ABSTRACTS, vol. 123, no. 13, 25 September 1995, Columbus, Ohio, US; abstract no. 161106, FEDORAK, RICHARD N. ET AL: "A novel colon-specific steroid prodrug enhances sodium chloride absorptio in rat colitis" XP002183496
CHEMICAL ABSTRACTS, vol. 118, no. 24, 14 June 1993, Columbus, Ohio, US; abstract no. 240666, FRIEND, D. ET AL: "Relative antiinflammatory effect of oral dexamethasone-.beta.-D-glucoside and dexamethasone in experimental IBD" XP002183497
CHEMICAL ABSTRACTS, vol. 115, no. 5, 5 August 1991, Columbus, Ohio, US; abstract no. 42233, FRIEND, D. R. ET AL: "Relative anti-inflammatory effect of oral dexamethasone-.beta.-D-glucosid and dexamethasone in experimental inflammatory bowel disease in guinea pigs" XP002183498
CHEMICAL ABSTRACTS, vol. 96, no. 17, 26 April 1982, Columbus, Ohio, US; abstract no. 136023, ALTHAUS, ZELDA R. ET AL: "Separation of some natural and synthetic corticosteroids in biological fluids and tissues by high-performance liquid chromatography" XP002183499
CHEMICAL ABSTRACTS, vol. 71, no. 3, 21 July 1969, Columbus, Ohio, US; abstract no. 13321, MATTOX, VERNON R. ET AL: "Synthesis of C-21 glucosiduronates of cortisone and related corticosteroids" XP002183500
CHEMICAL ABSTRACTS, vol. 102, no. 4, 28 January 1985, Columbus, Ohio, US; abstract no. 32032, FRIEND, DAVID R. ET AL: "Drug glycosides: potential prodrugs for colon-specific drug delivery" XP002183501
CHEMICAL ABSTRACTS, vol. 100, no. 10, 5 March 1984, Columbus, Ohio, US; abstract no. 73892, FRIEND, DAVID R. ET AL: "A colon-specific drug-delivery system based on drug glycosides and the glycosidases of colonic bacteria" XP002183502
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