Title:
PHARMACEUTICAL COMPOSITIONS CONTAINING STEROIDAL STRUCTURES AND USES THEREOF
Document Type and Number:
WIPO Patent Application WO2001051055
Kind Code:
A3
Abstract:
There is provided a pharmaceutical composition comprising (i) a compound of formula (I) wherein: X is a hydrocarbyl ring having at least 4 atoms in the ring; K is a hydrocarbyl group; Rs is a sulphamate group; (ii) optionally admixed with a pharmaceutically acceptable carrier, diluent, excipient or adjuvant, wherein the compound is present in an amount to provide a dosage of no greater than 200 mu g/day.
Inventors:
POTTER BARRY VICTOR LLOYD (GB)
REED MICHAEL JOHN (GB)
ELGER WALTER (DE)
REDDERSEN GUDRUN (DE)
PROSKE HENRICH-THOMAS (DE)
REED MICHAEL JOHN (GB)
ELGER WALTER (DE)
REDDERSEN GUDRUN (DE)
PROSKE HENRICH-THOMAS (DE)
Application Number:
PCT/GB2001/000094
Publication Date:
March 21, 2002
Filing Date:
January 11, 2001
Export Citation:
Assignee:
STERIX LTD (GB)
SCHERING AG (DE)
POTTER BARRY VICTOR LLOYD (GB)
REED MICHAEL JOHN (GB)
ELGER WALTER (DE)
REDDERSEN GUDRUN (DE)
PROSKE HENRICH THOMAS (DE)
SCHERING AG (DE)
POTTER BARRY VICTOR LLOYD (GB)
REED MICHAEL JOHN (GB)
ELGER WALTER (DE)
REDDERSEN GUDRUN (DE)
PROSKE HENRICH THOMAS (DE)
International Classes:
A61K31/56; A61K31/565; A61K31/567; A61K45/00; A61P5/30; A61P15/00; A61P15/18; A61P43/00; C07J1/00; C07J7/00; (IPC1-7): A61K31/56; A61P15/18; A61P15/00
Foreign References:
| US5556847A | 1996-09-17 |
Other References:
FOULKES, ROLY ET AL: "Immunological consequences of inhibiting dehydroepiandrosterone (DHEA) sulfatase in vivo", STEROID HORM. T-CELL CYTOKINE PROFILE (1997), 135-152. EDITOR(S): ROOK, G. A. W.;LIGHTMAN, STAFFORD L. PUBLISHER: SPRINGER, LONDON, UK., XP001040905
ELGER, WALTER ET AL: "Sulfamates of various estrogens are prodrugs with increased systemic and reduced hepatic estrogenicity at oral application", J. STEROID BIOCHEM. MOL. BIOL. (1995), 55(3/4), 395-403, XP000618892
ELGER, WALTER ET AL: "Novel estrogen sulfamates: a new approach to oral hormone therapy", EXPERT OPIN. INVEST. DRUGS (1998), 7(4), 575-589, XP002121926
BARTH, ASTRID ET AL: "Influence of subchronic administration of estradiol, ethinylestradiol and estradiol sulfamate on bile flow, bile acid excretion, and liver and biliary glutathione status in rats", ARCH. TOXICOL. (1997), 71(7), 443-449, XP000986430
ELGER, WALTER ET AL: "Sulfamates of various estrogens are prodrugs with increased systemic and reduced hepatic estrogenicity at oral application", J. STEROID BIOCHEM. MOL. BIOL. (1995), 55(3/4), 395-403, XP000618892
ELGER, WALTER ET AL: "Novel estrogen sulfamates: a new approach to oral hormone therapy", EXPERT OPIN. INVEST. DRUGS (1998), 7(4), 575-589, XP002121926
BARTH, ASTRID ET AL: "Influence of subchronic administration of estradiol, ethinylestradiol and estradiol sulfamate on bile flow, bile acid excretion, and liver and biliary glutathione status in rats", ARCH. TOXICOL. (1997), 71(7), 443-449, XP000986430
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