Title:
GPR7-SELECTIVE LIGAND AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2006/054641
Kind Code:
A1
Abstract:
A compound represented by Trp-Tyr-Lys-(X)n-Gly-Arg-AlaAla-Gly-Leu-Leu-Ser-Gly-Leu-NH2 or a pharmaceutically acceptable salt thereof is a GPR7-selective ligand. [In the formula, n is an integer of 2-10; and X's each independently represents -NH-(CH2)m-CO- (wherein m is an integer of 2-6), the group represented by the formula (1) (wherein l is 0 or 1) which may be substituted, etc.]
Inventors:
MATSUDA MASAO (JP)
TOKITA SHIGERU (JP)
KANATANI AKIO (JP)
KANESAKA MAKI (JP)
TOKITA SHIGERU (JP)
KANATANI AKIO (JP)
KANESAKA MAKI (JP)
Application Number:
PCT/JP2005/021121
Publication Date:
May 26, 2006
Filing Date:
November 17, 2005
Export Citation:
Assignee:
BANYU PHARMA CO LTD (JP)
MATSUDA MASAO (JP)
TOKITA SHIGERU (JP)
KANATANI AKIO (JP)
KANESAKA MAKI (JP)
MATSUDA MASAO (JP)
TOKITA SHIGERU (JP)
KANATANI AKIO (JP)
KANESAKA MAKI (JP)
International Classes:
C07K7/02; A61K38/00; A61P3/04; A61P3/10; A61P5/06; A61P25/06; A61P25/18; A61P25/20; A61P29/00; G01N33/15; G01N33/50
Domestic Patent References:
| WO2003082907A1 | 2003-10-09 |
Foreign References:
| JP2004049003A | 2004-02-19 | |||
| JP2004051622A | 2004-02-19 | |||
| JPS62228099A | 1987-10-06 | |||
| JP2004049003A | 2004-02-19 | |||
| JP2004051622A | 2004-02-19 |
Other References:
FUJII R ET AL: "Identification of a Neuropeptide Modified with Bromine as an Endogenous Ligand for GPR7.", J BIOL CHEM., vol. 277, no. 37, 13 September 2002 (2002-09-13), pages 34010 - 34016, XP002212837
TILLEY JW ET AL: "Analogs of Ac-CCK-7 incorporating dipeptide mimics in place of Met28-Gly29.", J MED CHEM., vol. 35, no. 21, 1998, pages 3774 - 3783, XP002995741
CALO G ET AL: "Structure-Activity Study of the Nociceptin (1-13)-NH 2 N-Terminal Tetrapeptide and Discovery of a Nociceptin Receptor Antagonist.", J MED CHEM., vol. 41, no. 18, 1998, pages 3360 - 3366, XP002995742
KAWASAKI K ET AL: "Amino acids and peptides. II. Modification of glycylglycine bond in methionine enkephalin.", BIOCHEM BIOPHYS RES COMMUN., vol. 106, no. 1, 1982, pages 113 - 116, XP002995743
SOFUKU S ET AL: "Syntheses of gramicidin S analogs containing-aminovaleric acid. [5-1'--Aminovaleric acid]-gramicidin S and [5-1',5'-1-bis(-aminovaleric acid]-gramicidin S.", BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN., vol. 50, no. 8, 1977, pages 2143 - 2147, XP002995744
SNYDER KR ET AL: "Synthesis and Opioid Activity of Dynorphin A-( 1-13)NHz Analogues Containing cis- and trans-4-Aminocyclohexanecarboxylic Acid.", JOURNAL OF MEDICINAL CHEMISTRY., vol. 36, no. 8, 1993, pages 1100 - 1103, XP002995745
YAMAZAKI T ET AL: "Peptidomimetic structures incorporating 2-aminocyclopentacarboxyl acids.", PEPT 1990 PROC EUR PEPT SYMP., 1991, pages 389 - 392, XP002995746
See also references of EP 1816136A4
MOLECULAR PHARMACOLOGY, vol. 55, 1999, pages 1101
TANAKA H. ET AL., PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 100, 2003, pages 6251 - 6256
FUJII R. ET AL., THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 277, 2002, pages 34010 - 34016
SHIMOMURA Y. ET AL., THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 277, 2002, pages 35826 - 35832
WINSKY-SOMMERER R. ET AL., SLEEP, vol. 26, 2003
GENOMICS, vol. 28, 1995, pages 84
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 84, 1987, pages 7413
MOLECULAR PHARMACOLOGY, vol. 55, 1999, pages 1101
SCIENCE, vol. 279, 1998, pages 84
TILLEY JW ET AL: "Analogs of Ac-CCK-7 incorporating dipeptide mimics in place of Met28-Gly29.", J MED CHEM., vol. 35, no. 21, 1998, pages 3774 - 3783, XP002995741
CALO G ET AL: "Structure-Activity Study of the Nociceptin (1-13)-NH 2 N-Terminal Tetrapeptide and Discovery of a Nociceptin Receptor Antagonist.", J MED CHEM., vol. 41, no. 18, 1998, pages 3360 - 3366, XP002995742
KAWASAKI K ET AL: "Amino acids and peptides. II. Modification of glycylglycine bond in methionine enkephalin.", BIOCHEM BIOPHYS RES COMMUN., vol. 106, no. 1, 1982, pages 113 - 116, XP002995743
SOFUKU S ET AL: "Syntheses of gramicidin S analogs containing
SNYDER KR ET AL: "Synthesis and Opioid Activity of Dynorphin A-( 1-13)NHz Analogues Containing cis- and trans-4-Aminocyclohexanecarboxylic Acid.", JOURNAL OF MEDICINAL CHEMISTRY., vol. 36, no. 8, 1993, pages 1100 - 1103, XP002995745
YAMAZAKI T ET AL: "Peptidomimetic structures incorporating 2-aminocyclopentacarboxyl acids.", PEPT 1990 PROC EUR PEPT SYMP., 1991, pages 389 - 392, XP002995746
See also references of EP 1816136A4
MOLECULAR PHARMACOLOGY, vol. 55, 1999, pages 1101
TANAKA H. ET AL., PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 100, 2003, pages 6251 - 6256
FUJII R. ET AL., THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 277, 2002, pages 34010 - 34016
SHIMOMURA Y. ET AL., THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 277, 2002, pages 35826 - 35832
WINSKY-SOMMERER R. ET AL., SLEEP, vol. 26, 2003
GENOMICS, vol. 28, 1995, pages 84
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 84, 1987, pages 7413
MOLECULAR PHARMACOLOGY, vol. 55, 1999, pages 1101
SCIENCE, vol. 279, 1998, pages 84
Attorney, Agent or Firm:
Hasegawa, Yoshiki (Ginza First Bldg. 10-6, Ginza 1-chome, Chuo-k, Tokyo 61, JP)
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