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Title:
GROWTH FACTOR ANCHORING TYPE BONE GRAFT MATERIAL, METHOD FOR PRODUCING GROWTH FACTOR ANCHORING TYPE BONE GRAFT MATERIAL, KIT FOR PRODUCING GROWTH FACTOR ANCHORING TYPE BONE GRAFT MATERIAL, AND METHOD FOR FORMING BONE
Document Type and Number:
WIPO Patent Application WO/2012/157339
Kind Code:
A1
Abstract:
This growth factor anchoring type bone graft material is characterized in that growth factor containing collagen-binding sites, which contains growth factor receptor agonist peptides and collagen-binding peptides, is bonded to a bone graft substrate obtained by exposing at least collagen fibers. The growth factor containing collagen-binding sites, which contains growth factor receptor agonist peptides and collagen-binding peptides, can be mixed with the bone graft substrate for preparation purposes, and has excellent osteogenic potential.

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Inventors:
UCHIDA KENTARO (JP)
NARUSE KOJI (JP)
TAKASO MASASHI (JP)
MIMA TAKEHIKO (JP)
MATSUSHITA OSAMU (JP)
HARAGUCHI TAKASHI (JP)
NISHI NOZOMU (JP)
Application Number:
PCT/JP2012/057829
Publication Date:
November 22, 2012
Filing Date:
March 26, 2012
Export Citation:
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Assignee:
SCHOOL JURIDICAL PERSON KITASATO INST (JP)
UNIV KAGAWA NAT UNIV CORP (JP)
UCHIDA KENTARO (JP)
NARUSE KOJI (JP)
TAKASO MASASHI (JP)
MIMA TAKEHIKO (JP)
MATSUSHITA OSAMU (JP)
HARAGUCHI TAKASHI (JP)
NISHI NOZOMU (JP)
International Classes:
A61L27/00; C07K17/02
Domestic Patent References:
WO2010087397A12010-08-05
WO2011142425A12011-11-17
Foreign References:
JP2010523671A2010-07-15
JP2010508912A2010-03-25
JP2007530099A2007-11-01
JP2009534125A2009-09-24
JP2010523671A2010-07-15
JP2002058485A2002-02-26
JP2003525696A2003-09-02
JP2009519052A2009-05-14
JP2010512967A2010-04-30
Other References:
VISSER R. ET AL.: "The effect of an rhBMP-2 absorbable collagen sponge-targeted systemon bone formation in vivo", BIOMATERIALS, vol. 30, 2009, pages 2032 - 2037, XP025947959
NISHI N. ET AL.: "Collagen-binding growth factors: Production and characterization of functional fusion proteins having a collagen-binding domain", PROC. NATL. ACAD. SCI. USA, vol. 95, 1998, pages 7018 - 7023, XP002948319
SHI C. ET AL.: "Regeneration of full-thickness abdominal wall defects in rats using collagenscaffolds loaded with collagen-binding basic fibroblast growth factor", BIOMATERIALS, vol. 32, January 2011 (2011-01-01), pages 753 - 759, XP027506435
IMEN EH. ET AL.: "Construction of multifunctional proteins for tissue engineering: Epidermalgrowth factor with collagen binding and cell adhesive activities", JOURNAL OF BIOTECHNOLOGY, vol. 139, 2009, pages 19 - 25, XP025796268
NOZOMU NISHI ET AL.: "Proc. Natl. Acad. Sci., USA", vol. 95, June 1998, MEDICAL SCIENCES, article "Collagen-binding growth factors: Production and characterization of functional fusion proteins having a collagen-binding domain", pages: 7018 - 7023
See also references of EP 2708246A4
Attorney, Agent or Firm:
KIMURA MITSURU (JP)
Mitsuru Kimura (JP)
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