Title:
GROWTH FACTOR RECEPTOR
Document Type and Number:
WIPO Patent Application WO1988007551
Kind Code:
A3
Abstract:
A 75-85 Kd glycopolypeptide, capable of acting as a receptor for polypeptide of the bombesin type, is isolated from the surface of Swiss 3T3 cells. Certain antagonists and antibodies to the glycopolypeptide are described, the antagonists being of quite different structure to bombesin e.g. [D-Pro<2>]-spantide, [D-Phe<5>]-spantide and position 5 variants thereof. The antagonists and antibodies are of interest medically in that they are able to influence cell proliferation that occurs under the influence of the bombesin-like polypeptides.
Inventors:
ROSENGURT ENRIQUE (GB)
ZACHARY IAN (GB)
WOLL PENELLA (GB)
ZACHARY IAN (GB)
WOLL PENELLA (GB)
Application Number:
PCT/GB1988/000255
Publication Date:
February 22, 1990
Filing Date:
March 31, 1988
Export Citation:
Assignee:
IMP CANCER RES TECH (GB)
International Classes:
C07K1/14; C07K1/22; C07K1/26; C07K7/06; G01N33/577; C07K14/00; C07K14/575; C07K14/705; C07K14/71; C07K16/00; C12N15/09; C12P21/02; G01N33/574; A61K38/00; C12R1/91; (IPC1-7): C07K15/00; A61K37/02; G01N33/574; C07K7/06; A61K39/395
Foreign References:
| US4481139A | 1984-11-06 |
Other References:
The Journal of Biological Chemistry; volume 262, no. 9, 25 March 1987, The American Society of Biological Chemists, Inc., (US), I. Zachary et al.: "Identification of a receptor for peptides of the bombesin family in Swiss 3T3 cells by affinity cross-linking", pages 3947-3950
Nature, volume 316, 29 August 1985, F. Cuttitta et al.: "Bombesin-like peptides can function as autocrine growth factors in human small-cell lung cancer", pages 823-826
Biological Abstracts, volume 83, D.M. Cirillo et al.: Receptor for bombesin with associated tyrosine kinase activity", see abstract no. 66775, & Mol. Cell. Biol. 1986, vol. 6, no.12, p. 4641-4649
Proc. Natl. Acad. Sci, USA, volume 82, November 1985, I. Zachary et al.: "High-affinity receptors for peptides of the bombesin family in Swiss 3T3 cells", pages 7616-7620
The Journal of Biological Chemistry, volume 262, no. 23, 15 August 1987, The American Society for Biochemistry and Molecular Biology, Inc., (US), R.M. Kris et al.: "Identification of the bombesin recptor on murine and human cells by cross-linking experiments", pages 11215-11220
Acta Chemica Scandinavica, volume B40, 1986, K. Folkers et al.: "Design and synthesis of antagonists of substance P", pages 295-302
Biological Abstracts/RMM, no. 33040010, J.E. Layton et al.: "The effect of bombesin antagonists on the growth of small cell lung cancer SCLC", see the title, & Symposia on Molecular and Cellular Biology, Los Angeles, California, USA, January 17-23, 1987, J. Cell. Biochem. Suppl. 1987, vol. 0, no. 11, part A, p. 32
Proc. Natl. Acad. Sci, USA, volume 85, no. 6, March 1988, P.J. Woll et al.: "(D-Arg1,D-Phe5,D-Trp7,9,Leu11)substance P, a potent bombesin antagonist in murine Swiss 3T3 cells, inhibits the growth of human small cell lung cancer cells in vitro", pages 1859-1863
Nature, volume 316, 29 August 1985, F. Cuttitta et al.: "Bombesin-like peptides can function as autocrine growth factors in human small-cell lung cancer", pages 823-826
Biological Abstracts, volume 83, D.M. Cirillo et al.: Receptor for bombesin with associated tyrosine kinase activity", see abstract no. 66775, & Mol. Cell. Biol. 1986, vol. 6, no.12, p. 4641-4649
Proc. Natl. Acad. Sci, USA, volume 82, November 1985, I. Zachary et al.: "High-affinity receptors for peptides of the bombesin family in Swiss 3T3 cells", pages 7616-7620
The Journal of Biological Chemistry, volume 262, no. 23, 15 August 1987, The American Society for Biochemistry and Molecular Biology, Inc., (US), R.M. Kris et al.: "Identification of the bombesin recptor on murine and human cells by cross-linking experiments", pages 11215-11220
Acta Chemica Scandinavica, volume B40, 1986, K. Folkers et al.: "Design and synthesis of antagonists of substance P", pages 295-302
Biological Abstracts/RMM, no. 33040010, J.E. Layton et al.: "The effect of bombesin antagonists on the growth of small cell lung cancer SCLC", see the title, & Symposia on Molecular and Cellular Biology, Los Angeles, California, USA, January 17-23, 1987, J. Cell. Biochem. Suppl. 1987, vol. 0, no. 11, part A, p. 32
Proc. Natl. Acad. Sci, USA, volume 85, no. 6, March 1988, P.J. Woll et al.: "(D-Arg1,D-Phe5,D-Trp7,9,Leu11)substance P, a potent bombesin antagonist in murine Swiss 3T3 cells, inhibits the growth of human small cell lung cancer cells in vitro", pages 1859-1863
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