Title:
PROTEIN HAVING ACTIVITY OF INHIBITING INFLAMMATION-INDUCING PHOSPHOLIPASE A2
Document Type and Number:
WIPO Patent Application WO/1988/007552
Kind Code:
A1
Abstract:
A protein having an activity of inhibiting inflammation-inducing phospholipase A2, which is induced from cells by administering glucocorticoid thereto and which has a molecular weight of, for example, 40 K and has an N-terminal amino acid sequence of N-terminal amino acid-Asp-Val-Pro-Ala-Ala-Asp-Leu-Ser-Asp.
Inventors:
INOUE KEIZO (JP)
IMAIZUMI ATSUSHI (JP)
KAMIMURA TAKASHI (JP)
SUWA YORIMASA (JP)
OKADA MASAHIRO (JP)
SUZUKI YOJI (JP)
KUDO ICHIRO (JP)
IMAIZUMI ATSUSHI (JP)
KAMIMURA TAKASHI (JP)
SUWA YORIMASA (JP)
OKADA MASAHIRO (JP)
SUZUKI YOJI (JP)
KUDO ICHIRO (JP)
Application Number:
PCT/JP1988/000318
Publication Date:
October 06, 1988
Filing Date:
March 30, 1988
Export Citation:
Assignee:
TEIJIN LTD (JP)
International Classes:
C12P21/00; A61K38/55; A61P29/00; C07K1/20; C07K14/00; C07K14/435; C07K14/47; A61K38/00; (IPC1-7): C07K15/06; A61K37/64; C07K15/12; C12P21/00
Domestic Patent References:
| WO1986006100A1 | 1986-10-23 | |||
| WO1986004094A1 | 1986-07-17 |
Foreign References:
| JPS6256429A | 1987-03-12 |
Other References:
CHEMICAL ABSTRACTS, Vol. 104, No. 11, 17 March 1986 (17. 03. 86) (Columbus, Ohio, U.S.A.) "Background and Discovery of Lipocortins", page 76, see Abstract No. 82112r, Agents Actions, 1985, 17 (3-4), 255-62
CHEMICAL ABSTRACTS, Vol. 101, No. 13 24 September 1984 (24. 09. 84) (Columbus, Ohio, U.S.A.) "Macrocortin and the Antiphospholipase Proteins", page 70, see Abstract No. 104127s, Adv. Inflammation Res., 1984, 8, 1-34
CHEMICAL ABSTRACTS, Vol. 100, No. 9, 27 February 1984 (27. 02. 84) (Columbus, Ohio, U.S.A.) "Further Characterization of the Glucocorticoid-Induced Antiphospholipase Protein "Renocortin" ", page 76, see Abstract No. 62061n, Biochem. Biophys. Res. Commun., 1983, 117(3), 878-84
CHEMICAL ABSTRACTS, Vol. 97, No. 9, 30 August 1982 (30. 08. 82) (Columbus, Ohio, U.S.A.) "Glucocorticoids Induce the Formation and Release of Antiinflammatory and Antophospholipase Proteins into the Peritoneal Cavity of the Rat", page 87, see Abstract No. 66596h, Br. J. Pharmacol, 1982, 76(1), 185-94
CHEMICAL ABSTRACTS, Vol. 101, No. 13 24 September 1984 (24. 09. 84) (Columbus, Ohio, U.S.A.) "Macrocortin and the Antiphospholipase Proteins", page 70, see Abstract No. 104127s, Adv. Inflammation Res., 1984, 8, 1-34
CHEMICAL ABSTRACTS, Vol. 100, No. 9, 27 February 1984 (27. 02. 84) (Columbus, Ohio, U.S.A.) "Further Characterization of the Glucocorticoid-Induced Antiphospholipase Protein "Renocortin" ", page 76, see Abstract No. 62061n, Biochem. Biophys. Res. Commun., 1983, 117(3), 878-84
CHEMICAL ABSTRACTS, Vol. 97, No. 9, 30 August 1982 (30. 08. 82) (Columbus, Ohio, U.S.A.) "Glucocorticoids Induce the Formation and Release of Antiinflammatory and Antophospholipase Proteins into the Peritoneal Cavity of the Rat", page 87, see Abstract No. 66596h, Br. J. Pharmacol, 1982, 76(1), 185-94
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