GUANIDINE COMPOUNDS AS ANESTHETICS AND FOR TREATMENT OF NERVOUS SYSTEM DISORDERS

Title:

GUANIDINE COMPOUNDS AS ANESTHETICS AND FOR TREATMENT OF NERVOUS SYSTEM DISORDERS

Document Type and Number:

WIPO Patent Application WO2003105779

Kind Code:

A3

Abstract:

Novel guanidine compounds having the formula (I) in which Rl, R2 and R4 are as defined, are effective as sodium channel blockers in neuronal mammalian cells and as anesthetics and/or analgesics, particularly local spinal and/or epidural anesthetics, for alleviation of neuropathic pain, for providing a neuroprotective effect, and for producing anticonvulsant effects.

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Inventors:

DRASNER KENNETH
WEBER KEVIN T

Application Number:

PCT/US2003/019127

Publication Date:

May 06, 2004

Filing Date:

June 16, 2003

Export Citation:

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Assignee:

MEDIQUEST THERAPEUTICS INC (US)

International Classes:

A61K31/4184; A61K31/454; A61K31/5377; A61P9/10; A61P23/00; A61P23/02; A61P25/00; A61P25/02; A61P25/04; A61P25/08; A61P43/00; C07D235/30; C07D405/06; C07D409/06; (IPC1-7): A61K31/415

Foreign References:

US5216003A

1993-06-01

Other References: