Title:
PHOSPHATIDYLINOSITOL-4-PHOSPHATE 5-KINASE, TYPE II BETA INHIBITORS FOR INHIBITING ANGIOGENESIS
Document Type and Number:
WIPO Patent Application WO2003105778
Kind Code:
A3
Abstract:
Compounds, compositions and methods are provided for modulating the expression of phosphatidylinositol-4- phosphate 5-kinase, type II beta. The compositions comprise oligonucleotides, targeted to nucleic acid encoding phosphatidylinositol-4-phosphate 5-kinase, type II beta. Methods of using these compounds for modulation of phosphatidylinositol-4-phosphate 5-kinase, type II beta expression and for diagnosis and treatment of disease associated with expression of phosphatidylinositol-4phosphate 5-kinase, type II beta are provided.
Inventors:
DOBIE KENNETH W (US)
FREIER SUSAN M (US)
FREIER SUSAN M (US)
Application Number:
PCT/US2003/019115
Publication Date:
May 13, 2004
Filing Date:
June 18, 2003
Export Citation:
Assignee:
ISIS PHARMACEUTICALS INC (US)
DOBIE KENNETH W (US)
FREIER SUSAN M (US)
DOBIE KENNETH W (US)
FREIER SUSAN M (US)
International Classes:
C12N9/12; C12N15/113; A61K38/00; A61K48/00; (IPC1-7): C07H21/04; A61K48/00; C12N15/00
Foreign References:
| US5665754A | 1997-09-09 | |||
| US6423751B1 | 2002-07-23 |
Other References:
CASTELLINO ET AL.: "A novel interaction between the Juxtamembrane region of the p55 tumor necrosis factor receptor and phosphatidylinositol-4-phosphate 5-kinase", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 272, no. 9, 28 February 1997 (1997-02-28), pages 5861 - 5870, XP002229259
ISHIHARA ET AL.: "Type I phosphatidylinositol-4-phosphate 5-kinases", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 273, no. 15, 10 April 1998 (1998-04-10), pages 8741 - 8748, XP002974305
ISHIHARA ET AL.: "Type I phosphatidylinositol-4-phosphate 5-kinases", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 273, no. 15, 10 April 1998 (1998-04-10), pages 8741 - 8748, XP002974305
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