Title:
GUANIDINE COMPOUNDS, AND USE THEREOF AS BINDING PARTNERS FOR 5-HT5 RECEPTORS
Document Type and Number:
WIPO Patent Application WO2005082871
Kind Code:
A3
Abstract:
The invention relates to guanidine compounds of general formula (I), corresponding enantiomeric, diastereomeric, and/or tautomeric forms thereof, and pharmaceutically acceptable salts thereof. The invention further relates to the use of guanidine compounds as binding partners for 5-HT5 receptors in order to treat diseases modulated by 5-HT5 receptor activity, especially treat neurodegenerative and neuropsychiatric disorders and the signs, symptoms, and malfunctions associated therewith.
Inventors:
NETZ ASTRID (DE)
AMBERG WILHELM (DE)
LANGE UDO (DE)
OCHSE MICHAEL (DE)
HUTCHINS CHARLES W (US)
GARCIA-LADONA FRANCISCO-XAVIER (DE)
WERNET WOLFGANG (DE)
KLING ANDREAS (DE)
AMBERG WILHELM (DE)
LANGE UDO (DE)
OCHSE MICHAEL (DE)
HUTCHINS CHARLES W (US)
GARCIA-LADONA FRANCISCO-XAVIER (DE)
WERNET WOLFGANG (DE)
KLING ANDREAS (DE)
Application Number:
PCT/EP2005/001521
Publication Date:
November 10, 2005
Filing Date:
February 15, 2005
Export Citation:
Assignee:
ABBOTT GMBH & CO KG (DE)
NETZ ASTRID (DE)
AMBERG WILHELM (DE)
LANGE UDO (DE)
OCHSE MICHAEL (DE)
HUTCHINS CHARLES W (US)
GARCIA-LADONA FRANCISCO-XAVIER (DE)
WERNET WOLFGANG (DE)
KLING ANDREAS (DE)
NETZ ASTRID (DE)
AMBERG WILHELM (DE)
LANGE UDO (DE)
OCHSE MICHAEL (DE)
HUTCHINS CHARLES W (US)
GARCIA-LADONA FRANCISCO-XAVIER (DE)
WERNET WOLFGANG (DE)
KLING ANDREAS (DE)
International Classes:
C07D231/56; C07D235/30; C07D237/22; C07D249/14; C07D261/14; C07D263/28; C07D277/48; C07D277/82; C07D285/08; C07D285/135; C07D333/36; C07D417/04; C07D285/12; (IPC1-7): C07D277/48; A61K31/425; C07D231/56; C07D237/22; C07D249/14; C07D261/14; C07D263/28; C07D277/82; C07D285/08; C07D285/12; C07D417/04
Domestic Patent References:
| WO1996005187A1 | 1996-02-22 | |||
| WO1995018126A1 | 1995-07-06 | |||
| WO1992016526A1 | 1992-10-01 | |||
| WO2002016318A1 | 2002-02-28 | |||
| WO1999020599A1 | 1999-04-29 | |||
| WO2002036544A1 | 2002-05-10 |
Foreign References:
| EP0545376A1 | 1993-06-09 | |||
| EP0259085A1 | 1988-03-09 | |||
| US4560690A | 1985-12-24 | |||
| JPS5936674A | 1984-02-28 | |||
| GB1031165A | 1966-05-25 |
Other References:
KATSURA, YOUSUKE ET AL: "Anti-Helicobacter pylori Agents. 5. 2-(Substituted guanidino)-4-arylthiazoles and Aryloxazole Analogues", JOURNAL OF MEDICINAL CHEMISTRY , CODEN: JMCMAR, vol. 45, no. 1, 2002, pages 143 - 150, XP002339344, ISSN: 0022-2623
KATSURA, YOUSUKE ET AL: "Anti-Helicobacter pylori Agents. 4. 2-(Substituted guanidino)-4-phenylthiazoles and Some Structurally Rigid Derivatives", JOURNAL OF MEDICINAL CHEMISTRY , CODEN: JMCMAR, vol. 43, no. 17, 2000, pages 3315 - 3321, XP002339345, ISSN: 0022-2623
HOGBERG, MARITA ET AL: "Bioisosteric modification of PETT-HIV-1 RT-inhibitors: synthesis and biological evaluation", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS , CODEN: BMCLE8, vol. 10, no. 3, 2000, pages 265 - 268, XP002339346, ISSN: 0960-894X
KATSURA, YOUSUKE ET AL: "Anti-Helicobacter pylori agents. 3. 2-[(Arylalkyl)guanidino]-4- furylthiazoles", JOURNAL OF MEDICINAL CHEMISTRY , CODEN: JMCMAR, vol. 42, no. 15, 1999, pages 2920 - 2926, XP002339347, ISSN: 0022-2623
GUPTA, S. ET AL: "Superpendentic Index: A novel topological descriptor for predicting biological activity", JOURNAL OF CHEMICAL INFORMATION AND COMPUTER SCIENCES , CODEN: JCISD8, vol. 39, no. 2, 1999, pages 272 - 277, XP002339348, ISSN: 0095-2338
DATABASE CAPLUS [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; KATSURA, YOSUKE ET AL: "Preparation of furylthiazoles as ulcer inhibitors", XP002341494, retrieved from STN Database accession no. 1997:195723
DATABASE CAPLUS [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; KATSURA, YOSUKE ET AL: "Preparation of guanidinothiazole derivatives as histamine H2 antagonists", XP002341495, retrieved from STN Database accession no. 1997:140933
DATABASE CAPLUS [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; KAWANISHI, YASUYUKI ET AL: "Synthesis and biological evaluation of a new reversely linked type of dual histamine H2 and gastrin receptor antagonist", XP002341496, retrieved from STN Database accession no. 1997:81087
DATABASE CAPLUS [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; "Preparation of 4-thienylthiazole derivatives as antiulcer and antibacterial agents", XP002341497, retrieved from STN Database accession no. 1997:42
GOEL, ANSHU ET AL: "Structure-Activity Study on Antiulcer Agents Using Wiener's Topological Index and Molecular Connectivity Index", JOURNAL OF CHEMICAL INFORMATION AND COMPUTER SCIENCES , CODEN: JCISD8, vol. 35, no. 3, 1995, pages 504 - 509, XP002339349, ISSN: 0095-2338
KATSURA, YOUSUKE ET AL: "Anti-Helicobacter pylori Agents. 4. 2-(Substituted guanidino)-4-phenylthiazoles and Some Structurally Rigid Derivatives", JOURNAL OF MEDICINAL CHEMISTRY , CODEN: JMCMAR, vol. 43, no. 17, 2000, pages 3315 - 3321, XP002339345, ISSN: 0022-2623
HOGBERG, MARITA ET AL: "Bioisosteric modification of PETT-HIV-1 RT-inhibitors: synthesis and biological evaluation", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS , CODEN: BMCLE8, vol. 10, no. 3, 2000, pages 265 - 268, XP002339346, ISSN: 0960-894X
KATSURA, YOUSUKE ET AL: "Anti-Helicobacter pylori agents. 3. 2-[(Arylalkyl)guanidino]-4- furylthiazoles", JOURNAL OF MEDICINAL CHEMISTRY , CODEN: JMCMAR, vol. 42, no. 15, 1999, pages 2920 - 2926, XP002339347, ISSN: 0022-2623
GUPTA, S. ET AL: "Superpendentic Index: A novel topological descriptor for predicting biological activity", JOURNAL OF CHEMICAL INFORMATION AND COMPUTER SCIENCES , CODEN: JCISD8, vol. 39, no. 2, 1999, pages 272 - 277, XP002339348, ISSN: 0095-2338
DATABASE CAPLUS [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; KATSURA, YOSUKE ET AL: "Preparation of furylthiazoles as ulcer inhibitors", XP002341494, retrieved from STN Database accession no. 1997:195723
DATABASE CAPLUS [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; KATSURA, YOSUKE ET AL: "Preparation of guanidinothiazole derivatives as histamine H2 antagonists", XP002341495, retrieved from STN Database accession no. 1997:140933
DATABASE CAPLUS [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; KAWANISHI, YASUYUKI ET AL: "Synthesis and biological evaluation of a new reversely linked type of dual histamine H2 and gastrin receptor antagonist", XP002341496, retrieved from STN Database accession no. 1997:81087
DATABASE CAPLUS [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; "Preparation of 4-thienylthiazole derivatives as antiulcer and antibacterial agents", XP002341497, retrieved from STN Database accession no. 1997:42
GOEL, ANSHU ET AL: "Structure-Activity Study on Antiulcer Agents Using Wiener's Topological Index and Molecular Connectivity Index", JOURNAL OF CHEMICAL INFORMATION AND COMPUTER SCIENCES , CODEN: JCISD8, vol. 35, no. 3, 1995, pages 504 - 509, XP002339349, ISSN: 0095-2338
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