Title:
GUANOSINE DERIVATIVE AND PRODUCTION METHOD THEREFOR
Document Type and Number:
WIPO Patent Application WO/2019/221024
Kind Code:
A1
Abstract:
[Problem] To develop a purine base derivative. [Solution] A guanosine derivative compound characterized by being represented by the formula, wherein one of R1 and R2 is H and the other is any of H, OH, OCH3, and F, R3 is any of a compound having a double bond or triple bond, a compound having an azido group, and a cyclic compound, and R4 is any of H, monophosphoric acid, diphosphoric acid, and triphosphoric acid. Thus, a guanosine derivative having a substituent at the 8-position is provided. Use of the guanosine derivative renders nucleic-acid labeling possible.
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Inventors:
XU YAN (JP)
ISHIZUKA TAKUMI (JP)
XIAO CHAODA (JP)
ZHAO PEIYAN (JP)
NISHII RYUICHI (JP)
ISHIZUKA TAKUMI (JP)
XIAO CHAODA (JP)
ZHAO PEIYAN (JP)
NISHII RYUICHI (JP)
Application Number:
PCT/JP2019/018755
Publication Date:
November 21, 2019
Filing Date:
May 10, 2019
Export Citation:
Assignee:
UNIV MIYAZAKI (JP)
International Classes:
C07H19/167; A61K49/00; C07B51/00; C07H19/173; C07B61/00
Domestic Patent References:
| WO2017040510A1 | 2017-03-09 | |||
| WO2003051881A1 | 2003-06-26 |
Foreign References:
| CN101921835A | 2010-12-22 | |||
| CN101550175A | 2009-10-07 | |||
| JP2011037796A | 2011-02-24 | |||
| JP2009114171A | 2009-05-28 |
Other References:
NAGESH, N. ET AL.: "A useful method for the synthesis of 8 azido-guanosine tri- and tetraphosphate: important substrates for many enzymic reactions", JOURNAL OF BIOCHEMICAL AND BIOPHYSICAL METHODS, vol. 35, no. 1, 1997, pages 61 - 66, XP055653535
NADLER, A. ET AL.: "8-Viny 1-2'-deoxyguanosine as a Fluorescent 2'-Deoxyguanosine Mimic for Investigating DNA Hybridization and Topology", ANGEW. CHEM. INT. ED., vol. 50, no. 23, 2011, pages 5392 - 5396
HOLZBERGER, B. ET AL.: "Enzymatic synthesis of 8- viny 1- and 8-styryl-2'-deoxyguanosine modified DNA-novel fluorescent molecular probes", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 22, no. 9, 2012, pages 3136 - 3139, XP0028410871
SCHULZ, B. S. ET AL.: "A new synthesis of 9-B-D-ribofuranosyluric acid and its 5'- monophosphate", TETRAHEDRON LETTERS, vol. 26, no. 44, 1985, pages 5421 - 5424, XP055653554
ISHIZUKA, T. ET AL.: "RNA imaging in vivo with 8- position modified guanosine derivatives", THE 45TH INTERNATIONAL SYMPOSIUM ON NUCLEIC ACIDS CHEMISTRY AND THE 2ND ANNUAL MEETING OF JAPAN SOCIEITY OF NUCLEIC ACIDS CHEMISTRY, 7 November 2018 (2018-11-07), pages 150 - 151
NADLER, A. ET AL.: "8-Viny 1-2'-deoxyguanosine as a Fluorescent 2'-Deoxyguanosine Mimic for Investigating DNA Hybridization and Topology", ANGEW. CHEM. INT. ED., vol. 50, no. 23, 2011, pages 5392 - 5396
HOLZBERGER, B. ET AL.: "Enzymatic synthesis of 8- viny 1- and 8-styryl-2'-deoxyguanosine modified DNA-novel fluorescent molecular probes", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 22, no. 9, 2012, pages 3136 - 3139, XP0028410871
SCHULZ, B. S. ET AL.: "A new synthesis of 9-B-D-ribofuranosyluric acid and its 5'- monophosphate", TETRAHEDRON LETTERS, vol. 26, no. 44, 1985, pages 5421 - 5424, XP055653554
ISHIZUKA, T. ET AL.: "RNA imaging in vivo with 8- position modified guanosine derivatives", THE 45TH INTERNATIONAL SYMPOSIUM ON NUCLEIC ACIDS CHEMISTRY AND THE 2ND ANNUAL MEETING OF JAPAN SOCIEITY OF NUCLEIC ACIDS CHEMISTRY, 7 November 2018 (2018-11-07), pages 150 - 151
Attorney, Agent or Firm:
KAWAGUCHI Takayoshi (JP)
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