Title:
HALOGEN SUBSTITUTED COMPOUND, AND PREPARATION METHOD THEREFOR AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2021/022761
Kind Code:
A1
Abstract:
The present invention relates to a preparation method for a halogen substituted compound. A piperazine derivative represented as formula I reacts with a halogenated acetyl halide derivative represented as formula VI to generate the halogen substituted compound represented as formula II. The present invention further relates to a preparation method for a pyrazole derivative from the halogen substituted compound. The halogen substituted compound represented as formula II reacts with methylhydrazine, and a pyrazole ring is closed to generate a halogen substituted alkyl-1-methylpyrazole derivative represented as formula IV; or the halogen substituted compound represented as formula II reacts with methylhydrazine benzaldehyde hydrazone to generate a hydrazone compound represented as formula III, and under the action of an acid, a pyrazole ring is closed to generate the halogen substituted alkyl-1-methylpyrazole derivative represented as formula IV. The present invention also relates to the structure of an intermediate compound. The preparation methods for the halogen substituted compound and the pyrazole derivative according to the present invention are suitable for industrial production.
Inventors:
WANG MINGCHUN (CN)
LI QINGYI (CN)
LI QINGYI (CN)
Application Number:
PCT/CN2019/126839
Publication Date:
February 11, 2021
Filing Date:
December 20, 2019
Export Citation:
Assignee:
WANG MINGCHUN (CN)
International Classes:
C07D295/104; A01N43/56; A01P3/00; C07D231/14; C07D295/145
Domestic Patent References:
| WO2003051820A1 | 2003-06-26 | |||
| WO2003051820A1 | 2003-06-26 | |||
| WO1992012970A1 | 1992-08-06 | |||
| WO2009043444A1 | 2009-04-09 | |||
| WO2009133178A1 | 2009-11-05 | |||
| WO2012025469A1 | 2012-03-01 | |||
| WO2009000442A2 | 2008-12-31 |
Foreign References:
| CN110577503A | 2019-12-17 | |||
| CN107987021A | 2018-05-04 | |||
| CN107663172A | 2018-02-06 | |||
| CN107987021A | 2018-05-04 | |||
| CN107663172A | 2018-02-06 | |||
| EP2008996A1 | 2008-12-31 |
Other References:
See also references of EP 4008715A4
Attorney, Agent or Firm:
CHANGZHOU JINZHITAN INTELLECTUAL PROPERTY AGENCY FIRM (GENERAL PARTNERSHIP) (CN)
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