Title:
HEAT-RESISTANT RECOMBINANT HOST, METHOD FOR PRODUCING HEAT-RESISTANT RECOMBINANT HOST, METHOD FOR IMPARTING HEAT RESISTANCE TO HOST, AND METHOD FOR PRODUCING USEFUL SUBSTANCE
Document Type and Number:
WIPO Patent Application WO/2021/246522
Kind Code:
A1
Abstract:
The purpose of the present invention is to provide a host imparted with heat resistance. In one aspect, the present disclosure provides a heat-resistant recombinant host (e.g., cell, organism) operably containing a nucleic acid encoding a transgene group for proteins which are at least two enzymes. The enzymes can be used in the same primary metabolic pathway. In one embodiment, this heat-resistant recombinant host according to the present disclosure has a transgene group such that the transgene group can be expressed, the transgene group encoding a group of enzymes that play a part in at least one primary metabolic pathway such that the pathway can function. Compared to an original host without the transgene group, such a heat-resistant recombinant host is imparted with heat resistance, and is regarded as a heat-resistant host.
Inventors:
URAJI MISUGI (JP)
TSUGE KENJI (JP)
KONDO AKIHIKO (JP)
TSUGE KENJI (JP)
KONDO AKIHIKO (JP)
Application Number:
PCT/JP2021/021404
Publication Date:
December 09, 2021
Filing Date:
June 04, 2021
Export Citation:
Assignee:
UNIV KOBE NAT UNIV CORP (JP)
International Classes:
C12N15/52; C12N1/00; C12N1/13; C12N1/15; C12N1/21; C12N5/10; C12N15/31; C12P1/00; C12P1/02; C12P1/04
Foreign References:
| JPS57166992A | 1982-10-14 |
Other References:
KOBAYASHI, YOSUKE ET AL.: "Optimization of expression of the Pentose Phosphate Pathway (PPP) genes for xylose utilization in an ethanologenic recombinant yeast, Saccharomyces cerevisiae IR-2", LECTURE ABSTRACTS OF CONFERENCE OF JAPAN SOCIETY OF BIOSCIENCE, BIOTECHNOLOGY, AND AGROCHEMISTRY, 2016
MURATA, MASAYUKI ET AL.: "Identification and pathway analysis for essential genes of high-temperature growth limit temperature in Escherichia coli", LECTURE ABSTRACTS OF THE 32ND ANNUAL MEETING OF THE MOLECULAR BIOLOGY SOCIETY OF JAPAN, vol. 32, 2009
KOSAKA, TOMOYUKI ET AL.: "Heat resistance and thermophilization of thermotolerant Zymomonas mobilis", LECTURE ABSTRACTS OF THE ANNUAL MEETING OF JAPAN SOCIETY FOR BIOSCIENCE, BIOTECHNOLOGY, AND AGROCHEMISTRY, 2015
MURATA, MASAYUKI ET AL.: "Identification and pathway analysis for essential genes of high-temperature growth limit temperature in Escherichia coli", LECTURE ABSTRACTS OF THE 32ND ANNUAL MEETING OF THE MOLECULAR BIOLOGY SOCIETY OF JAPAN, vol. 32, 2009
KOSAKA, TOMOYUKI ET AL.: "Heat resistance and thermophilization of thermotolerant Zymomonas mobilis", LECTURE ABSTRACTS OF THE ANNUAL MEETING OF JAPAN SOCIETY FOR BIOSCIENCE, BIOTECHNOLOGY, AND AGROCHEMISTRY, 2015
Attorney, Agent or Firm:
YAMAMOTO, Shusaku et al. (JP)
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