HEMOSTATIC COMPOSITION AND PREPARATION METHOD THEREFOR

Title:

HEMOSTATIC COMPOSITION AND PREPARATION METHOD THEREFOR

Document Type and Number:

WIPO Patent Application WO/2020/108670

Kind Code:

A2

Abstract:

Provided is a hemostatic composition comprising trypsin and zeolite, wherein pore channels of the zeolite are micropores, the zeolite contains divalent metal cations, and the mass ratio of the trypsin to the zeolite is 1:200-4:10. In the present invention, the trypsin specifically binds to the zeolite, allowing the trypsin to maintain a certain conformation on the surface of the zeolite and to obtain a higher procoagulant activity, thereby obtaining a hemostatic composition with an excellent blood coagulation effect. The hemostatic composition of the present invention has the advantages of a simple preparation method, low cost and convenient use, and can be widely used in hemostasis during trauma and operations, especially in emergent hemostasis in hemophilia patients.

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Inventors:

FAN JIE (CN)
YU LISHA (CN)
XIAO LIPING (CN)
CHEN HAO (CN)
SHANG XIAOQIANG (CN)

Application Number:

PCT/CN2020/074061

Publication Date:

June 04, 2020

Filing Date:

January 28, 2020

Export Citation:

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Assignee:

UNIV ZHEJIANG (CN)

International Classes:

A61L15/16; A61L15/18; A61L15/38; A61L33/02; A61L33/16

Foreign References:

US4822349A	1989-04-18
US7858123B2	2010-12-28
US7604819B2	2009-10-20
US8703634B2	2014-04-22

Other References: