Title:
HEPARANASE-ACTIVITY INHIBITOR, WRINKLE AMELIORATING AGENT CONTAINING SAME, AND PHARMACEUTICAL COMPOSITION
Document Type and Number:
WIPO Patent Application WO/2011/040495
Kind Code:
A1
Abstract:
Disclosed is a heparanase-activity inhibitor containing as an active ingredient a 4-alkylresorcinol represented by the belowmentioned formula (I) (wherein R represents a straight-chain or branched alkyl group having 1-6 carbon atoms).
Inventors:
IRIYAMA SHUNSUKE (JP)
FUKUNISHI HIROTADA (JP)
SUETSUGU MASARU (JP)
AMANO SATOSHI (JP)
FUKUNISHI HIROTADA (JP)
SUETSUGU MASARU (JP)
AMANO SATOSHI (JP)
Application Number:
PCT/JP2010/066997
Publication Date:
April 07, 2011
Filing Date:
September 29, 2010
Export Citation:
Assignee:
SHISEIDO CO LTD (JP)
IRIYAMA SHUNSUKE (JP)
FUKUNISHI HIROTADA (JP)
SUETSUGU MASARU (JP)
AMANO SATOSHI (JP)
IRIYAMA SHUNSUKE (JP)
FUKUNISHI HIROTADA (JP)
SUETSUGU MASARU (JP)
AMANO SATOSHI (JP)
International Classes:
A61K31/05; A61K8/34; A61P9/00; A61P17/02; A61P35/00; A61P35/04; A61P43/00; A61Q19/08
Domestic Patent References:
| WO2009123215A1 | 2009-10-08 | |||
| WO2003084302A2 | 2003-10-16 |
Foreign References:
| JP2007254412A | 2007-10-04 | |||
| JPH02292213A | 1990-12-03 | |||
| JPH0249715A | 1990-02-20 | |||
| JP2006124358A | 2006-05-18 | |||
| JP2009056717W | 2009-03-31 | |||
| JPH0249715A | 1990-02-20 | |||
| JP2006124358A | 2006-05-18 | |||
| JP2007254412A | 2007-10-04 | |||
| JPH0651619A | 1994-02-25 | |||
| US2093778A | 1937-09-21 | |||
| GB1581428A | 1980-12-10 | |||
| JP2002167344A | 2002-06-11 | |||
| JP2001163794A | 2001-06-19 | |||
| JP2000503660A | 2000-03-28 | |||
| JPH11335235A | 1999-12-07 | |||
| JP2002580892A | 2002-04-11 | |||
| JP2003502054A | 2003-01-21 |
Other References:
ISRAEL VLODAVSKY ET AL.: "Mammalian heparanase: involvement in cancer metastasis, angiogenesis and normal development", CANCER BIOLOGY, vol. 12, 2002, pages 121 - 129, XP008154125, DOI: doi:10.1006/scbi.2001.0420
EYAL ZCHARIA ET AL.: "Heparanase accelates wound angiogenesis and wound healing in mouse and rat models", THE FASEB JOURNAL, vol. 19, February 2005 (2005-02-01), pages 211 - 221, XP008154187
See also references of EP 2484349A4
VLODAVSKY I. ET AL., SEMIN CANCER BIOL., vol. 12, no. 2, 2002, pages 121 - 129
ZACHARIA E. ET AL., FASEB J., vol. 19, no. 2, February 2005 (2005-02-01), pages 211 - 21
K. KAJIYA ET AL., AM. J. PATHOL., vol. 169, no. 4, 2006, pages 1496 - 1503
EYAL ZCHARIA ET AL.: "Heparanase accelates wound angiogenesis and wound healing in mouse and rat models", THE FASEB JOURNAL, vol. 19, February 2005 (2005-02-01), pages 211 - 221, XP008154187
See also references of EP 2484349A4
VLODAVSKY I. ET AL., SEMIN CANCER BIOL., vol. 12, no. 2, 2002, pages 121 - 129
ZACHARIA E. ET AL., FASEB J., vol. 19, no. 2, February 2005 (2005-02-01), pages 211 - 21
K. KAJIYA ET AL., AM. J. PATHOL., vol. 169, no. 4, 2006, pages 1496 - 1503
Attorney, Agent or Firm:
AOKI Atsushi et al. (JP)
Aoki 篤 (JP)
Aoki 篤 (JP)
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