HETEROARYL DERIVATIVE COMPOUND AS STAT3 INHIBITOR, AND USE THEREOF

WIPO Patent Application WO/2023/038481

A1

The present invention relates to a heteroaryl derivative compound having STAT3 inhibitory activity, and a use thereof. The heteroaryl derivative compound according to the present invention exhibits excellent STAT3-selective inhibitory activity by binding to the SH2 domain of STAT3 and can thus be highly effectively used for preventing or treating STAT3-related diseases.

SHIM TAE JIN (KR)
KIM JI HOON (KR)
LEE JUN HO (KR)
LEE MIN BUM (KR)
LIM JAE SUNG (KR)
RHO JUN GI (KR)
CHOI NU RI (KR)
LEE HYEWON (KR)

PCT/KR2022/013579

March 16, 2023

September 08, 2022

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FROMBIO CO LTD (KR)

C07D333/56; A61K31/381; A61K31/4436; A61P1/16; A61P35/00; A61P37/00; A61P43/00; C07D409/06

WO2001007431A2

2001-02-01

CN104844563A	2015-08-19
CN110981868A	2020-04-10

LIU, M.-S. et al. Dual catalysis relay: coupling of aldehydes and alkenes enabled by visible-light and NHC-catalyzed cross-double C-H functionalizations. ACS Catalysis. 19 July 2021, vol. 11, pp. 9715-9721.
ZHANG MINGMING, ZHU WEILIANG, LI YINGXIA: "Discovery of novel inhibitors of signal transducer and activator of transcription 3 (STAT3) signaling pathway by virtual screening", EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, ELSEVIER, AMSTERDAM, NL, vol. 62, 1 April 2013 (2013-04-01), AMSTERDAM, NL , pages 301 - 310, XP093045557, ISSN: 0223-5234, DOI: 10.1016/j.ejmech.2013.01.009

KIM, Kyeongkyo et al. (KR)

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