Title:
HETEROATOM-SUBSTITUTED AROMATIC COMPOUND, AND PREPARATION METHOD THEREFOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/274258
Kind Code:
A1
Abstract:
Provided are a heteroatom-substituted aromatic compound, and a preparation method therefor and the use thereof, which belong to the field of medicinal chemistry. The compound is a compound as represented by formula I, or a salt, a stereoisomer, a solvate, or a prodrug thereof. The compound can be used for preparing a central inhibitory drug and/or an analgesic drug that exerts a systemic anesthetic effect on an animal or a human being via an intravenous route, wherein the intravenous injection can exert quick-acting and short-acting systemic anesthetic and/or analgesic effects. The compound has a high therapeutic index, high safety, shorter wake-up time, better wake-up quality and better analgesic effect, and provides a great development value and clinical application prospects for the fields of intravenous injection analgesia, systemic anesthesia and other clinical applications of anesthesia.
Inventors:
LIU JIN (CN)
KE BOWEN (CN)
KE BOWEN (CN)
Application Number:
PCT/CN2022/102054
Publication Date:
January 05, 2023
Filing Date:
June 28, 2022
Export Citation:
Assignee:
WEST CHINA HOSPITAL SICHUAN UNIV (CN)
International Classes:
C07D295/14; A61K31/438; A61K31/5375; A61P23/00; A61P25/20
Domestic Patent References:
| WO2005025498A2 | 2005-03-24 |
Foreign References:
| CN114948953A | 2022-08-30 | |||
| CN1989099A | 2007-06-27 | |||
| CN111153851A | 2020-05-15 | |||
| GB895601A | 1962-05-02 |
Other References:
DATABASE REGISTRY 6 January 2021 (2021-01-06), ANONYMOUS : "-4-Morpholineacetamide, N-(2,6-dimethylphenyl)-3,5-dimethyl- (CA INDEX NAME) ", XP093018171, retrieved from STN Database accession no. 2567791-20-0
Attorney, Agent or Firm:
GAOYUNG INTELLECTUAL PROPERTY AGENCY (GENERAL PARTNERSHIP) (CN)
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