Title:
IMIDAZOLE COMPOUND, AND INTERMEDIATE AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/274257
Kind Code:
A1
Abstract:
An imidazole compound as shown in formula I or a pharmaceutically acceptable salt and an intermediate thereof. The imidazole compound as shown in formula I can significantly inhibit AA-induced platelet aggregation, improves MCAO/R-induced rat cerebral ischemia injury, has excellent metabolic stability, and can improve the distribution of a drug within the brain tissue, such that the pharmacodynamic activity of the imidazole compound in treatment of dyskinesia associated with acute thrombotic cerebral infarction and cerebral infarction is improved.
Inventors:
LI XIAOQIN (CN)
CHEN JIANFANG (CN)
CHEN JIANFANG (CN)
Application Number:
PCT/CN2022/102041
Publication Date:
January 05, 2023
Filing Date:
June 28, 2022
Export Citation:
Assignee:
ZHUGE GUOQIN (CN)
LI XIAOQIN (CN)
LI XIAOQIN (CN)
International Classes:
C07D233/64; A61K31/415; A61P7/00; A61P9/00; C07D233/56; C07D403/10; C07D403/12; C07D413/10; C07D413/12
Domestic Patent References:
| WO1989006233A1 | 1989-07-13 |
Foreign References:
| CN1061410A | 1992-05-27 | |||
| US5376666A | 1994-12-27 | |||
| US4226878A | 1980-10-07 | |||
| CN1082538A | 1994-02-23 | |||
| CN1082041A | 1994-02-16 | |||
| GB2272899A | 1994-06-01 | |||
| US4562199A | 1985-12-31 | |||
| JPS6239576A | 1987-02-20 | |||
| CN110914254A | 2020-03-24 | |||
| CN110506037A | 2019-11-26 |
Other References:
SARKAR ABHIJNAN, FORMENTI DARIO, FERRETTI FRANCESCO, KREYENSCHULTE CARSTEN, BARTLING STEPHAN, JUNGE KATHRIN, BELLER MATTHIAS, RAGA: "Iron/N-doped graphene nano-structured catalysts for general cyclopropanation of olefins", CHEMICAL SCIENCE, ROYAL SOCIETY OF CHEMISTRY, UNITED KINGDOM, vol. 11, no. 24, 24 June 2020 (2020-06-24), United Kingdom , pages 6217 - 6221, XP055924290, ISSN: 2041-6520, DOI: 10.1039/D0SC01650K
DANIELA MARIA CARMINATI; DANIELA INTRIERI; ALESSANDRO CASELLI; STÉPHANE LE GAC; BERNARD BOITREL; LUCIO TOMA; LAURA LEGNANI; EMMA G: "Designing ‘Totem’ C2‐Symmetrical Iron Porphyrin Catalysts for Stereoselective Cyclopropanations", CHEMISTRY - A EUROPEAN JOURNAL, JOHN WILEY & SONS, INC, DE, vol. 22, no. 38, 24 August 2016 (2016-08-24), DE, pages 13599 - 13612, XP071880318, ISSN: 0947-6539, DOI: 10.1002/chem.201602289
DANIELA MARIA CARMINATI; DANIELA INTRIERI; ALESSANDRO CASELLI; STÉPHANE LE GAC; BERNARD BOITREL; LUCIO TOMA; LAURA LEGNANI; EMMA G: "Designing ‘Totem’ C2‐Symmetrical Iron Porphyrin Catalysts for Stereoselective Cyclopropanations", CHEMISTRY - A EUROPEAN JOURNAL, JOHN WILEY & SONS, INC, DE, vol. 22, no. 38, 24 August 2016 (2016-08-24), DE, pages 13599 - 13612, XP071880318, ISSN: 0947-6539, DOI: 10.1002/chem.201602289
Attorney, Agent or Firm:
SHANGHAI BESHINING LAW OFFICE (CN)
Download PDF: