Title:
HETEROCYCLIC COMPOUND AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2020/004536
Kind Code:
A1
Abstract:
Provided is a heterocyclic compound having orexin receptor type 2 agonist activity. A compound represented by formula (I): [in the formula, each symbol is as described in the description] or a salt thereof has orexin receptor type 2 agonist activity and is useful as an agent for the prevention or treatment of narcolepsy.
Inventors:
FUJIMOTO TATSUHIKO (JP)
FUKUDA KOICHIRO (JP)
SUGIMOTO HIROMICHI (JP)
RIKIMARU KENTARO (JP)
BANNO YOSHIHIRO (JP)
MATSUMOTO TAKAHIRO (JP)
TOKUNAGA NORIHITO (JP)
TOMATA YOSHIHIDE (JP)
ISHICHI YUJI (JP)
MARUI SHOGO (JP)
ODA TSUNEO (JP)
MIYAZAKI TOHRU (JP)
HOASHI YASUTAKA (JP)
HATTORI YASUSHI (JP)
KAJITA YUICHI (JP)
MIYANOHANA YUHEI (JP)
KOIKE TATSUKI (JP)
FUKUDA KOICHIRO (JP)
SUGIMOTO HIROMICHI (JP)
RIKIMARU KENTARO (JP)
BANNO YOSHIHIRO (JP)
MATSUMOTO TAKAHIRO (JP)
TOKUNAGA NORIHITO (JP)
TOMATA YOSHIHIDE (JP)
ISHICHI YUJI (JP)
MARUI SHOGO (JP)
ODA TSUNEO (JP)
MIYAZAKI TOHRU (JP)
HOASHI YASUTAKA (JP)
HATTORI YASUSHI (JP)
KAJITA YUICHI (JP)
MIYANOHANA YUHEI (JP)
KOIKE TATSUKI (JP)
Application Number:
PCT/JP2019/025554
Publication Date:
January 02, 2020
Filing Date:
June 27, 2019
Export Citation:
Assignee:
TAKEDA PHARMACEUTICALS CO (JP)
International Classes:
C07D211/56; A61K31/445; A61K31/506; A61P25/00; A61P25/20; A61P43/00; C07D401/14; C07D405/14
Domestic Patent References:
| WO2017135306A1 | 2017-08-10 | |||
| WO2016133160A1 | 2016-08-25 | |||
| WO2016199906A1 | 2016-12-15 | |||
| WO2019027003A1 | 2019-02-07 | |||
| WO2019027058A1 | 2019-02-07 | |||
| WO2015073707A1 | 2015-05-21 | |||
| WO2015048091A1 | 2015-04-02 | |||
| WO2015147240A1 | 2015-10-01 | |||
| WO2012137982A9 | 2013-02-14 | |||
| WO2015088000A1 | 2015-06-18 | |||
| WO2016133160A1 | 2016-08-25 | |||
| WO2016199906A1 | 2016-12-15 | |||
| WO2001000663A2 | 2001-01-04 |
Foreign References:
| JP2012506374A | 2012-03-15 | |||
| JPS63190876A | 1988-08-08 | |||
| JPH11514333A | 1999-12-07 | |||
| JP2001500852A | 2001-01-23 | |||
| JP2018125332A | 2018-08-09 |
Other References:
CELL, vol. 92, 1998, pages 573 - 585
CELL, vol. 98, 1999, pages 437 - 451
PROC. NATL. ACAD. SCI. USA, vol. 101, 2004, pages 4649 - 4654
NEURON, vol. 38, 2003, pages 715 - 730
CNS DRUGS, vol. 27, 2013, pages 83 - 90
CELL METABOLISM, vol. 9, 2009, pages 64 - 76
NEUROSCIENCE, vol. 121, 2003, pages 855 - 863
RESPIRATION, vol. 71, 2004, pages 575 - 579
PEPTIDES, vol. 23, 2002, pages 1683 - 1688
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, vol. 66, 2015, pages 2522 - 2533
BRAIN, vol. 130, 2007, pages 1586 - 1595
SHIN JIKKENKAGAKU KOUZAL. F. TIETZETH. EICHERNANKODO: "Chemical Society of Japan", vol. 14-15, article "Fine Organic Chemistry"
"ORGANIC SYNTHESES Collective", vol. I-VII, JOHN WILEY & SONS INC, article "Organic Name Reactions, the Reaction Mechanism and Essence"
KIYOSHI TOMIOKAKAGAKUDOJIN: "Modern Organic Synthesis in the Laboratory A Collection of Standard Experimental Procedures", vol. 1-14, 1989, VCH PUBLISHERS INC, article "Comprehensive Organic Transformations"
THEODORA W. GREENEPETER G. M. WUTS: "Protective Groups in Organic Synthesis", 2004, WILEY-INTERSCIENCE, INC.
IYAKUHINKAIHATSU: "Development of Pharmaceuticals", vol. 7, 1990, HIROKAWA SHOTEN, article "Design of Molecules", pages: 163 - 198
BIOCHEM. J., vol. 340, no. 1, 1999, pages 283 - 289
CELL, vol. 98, 1999, pages 437 - 451
PROC. NATL. ACAD. SCI. USA, vol. 101, 2004, pages 4649 - 4654
NEURON, vol. 38, 2003, pages 715 - 730
CNS DRUGS, vol. 27, 2013, pages 83 - 90
CELL METABOLISM, vol. 9, 2009, pages 64 - 76
NEUROSCIENCE, vol. 121, 2003, pages 855 - 863
RESPIRATION, vol. 71, 2004, pages 575 - 579
PEPTIDES, vol. 23, 2002, pages 1683 - 1688
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, vol. 66, 2015, pages 2522 - 2533
BRAIN, vol. 130, 2007, pages 1586 - 1595
SHIN JIKKENKAGAKU KOUZAL. F. TIETZETH. EICHERNANKODO: "Chemical Society of Japan", vol. 14-15, article "Fine Organic Chemistry"
"ORGANIC SYNTHESES Collective", vol. I-VII, JOHN WILEY & SONS INC, article "Organic Name Reactions, the Reaction Mechanism and Essence"
KIYOSHI TOMIOKAKAGAKUDOJIN: "Modern Organic Synthesis in the Laboratory A Collection of Standard Experimental Procedures", vol. 1-14, 1989, VCH PUBLISHERS INC, article "Comprehensive Organic Transformations"
THEODORA W. GREENEPETER G. M. WUTS: "Protective Groups in Organic Synthesis", 2004, WILEY-INTERSCIENCE, INC.
IYAKUHINKAIHATSU: "Development of Pharmaceuticals", vol. 7, 1990, HIROKAWA SHOTEN, article "Design of Molecules", pages: 163 - 198
BIOCHEM. J., vol. 340, no. 1, 1999, pages 283 - 289
Attorney, Agent or Firm:
TAKASHIMA, Hajime (JP)
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