Title:
HETEROCYCLIC COMPOUND AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2020/004537
Kind Code:
A1
Abstract:
Provided is a heterocyclic compound that has orexin-2 type receptor agonistic activity. A compound represented by formula (I) [wherein each symbol is as defined in the description] or a salt thereof has orexin-2 type receptor agonistic activity and is useful as a preventive or therapeutic agent for narcolepsy.
Inventors:
ODA TSUNEO (JP)
ITO YOSHITERU (JP)
MIYAZAKI TOHRU (JP)
TAKEUCHI KOHEI (JP)
TOKUNAGA NORIHITO (JP)
HOASHI YASUTAKA (JP)
HATTORI YASUSHI (JP)
IMAMURA KEISUKE (JP)
KAJITA YUICHI (JP)
MIYANOHANA YUHEI (JP)
SUGIMOTO TAKAHIRO (JP)
KOIKE TATSUKI (JP)
AINIWAER DILIHUMAER (JP)
ITO YOSHITERU (JP)
MIYAZAKI TOHRU (JP)
TAKEUCHI KOHEI (JP)
TOKUNAGA NORIHITO (JP)
HOASHI YASUTAKA (JP)
HATTORI YASUSHI (JP)
IMAMURA KEISUKE (JP)
KAJITA YUICHI (JP)
MIYANOHANA YUHEI (JP)
SUGIMOTO TAKAHIRO (JP)
KOIKE TATSUKI (JP)
AINIWAER DILIHUMAER (JP)
Application Number:
PCT/JP2019/025555
Publication Date:
January 02, 2020
Filing Date:
June 27, 2019
Export Citation:
Assignee:
TAKEDA PHARMACEUTICALS CO (JP)
International Classes:
C07D207/14; A61K31/40; A61K31/426; A61K31/4439; A61K31/445; A61P25/18; A61P25/26; C07D211/56; C07D401/06; C07D401/14; C07D405/06; C07D405/12; C07D405/14; C07D417/06; C07D417/14
Domestic Patent References:
| WO2017135306A1 | 2017-08-10 | |||
| WO2019027058A1 | 2019-02-07 | |||
| WO2015073707A1 | 2015-05-21 | |||
| WO2015048091A1 | 2015-04-02 | |||
| WO2015147240A1 | 2015-10-01 | |||
| WO2012137982A9 | 2013-02-14 | |||
| WO2015088000A1 | 2015-06-18 | |||
| WO2016133160A1 | 2016-08-25 | |||
| WO2016199906A1 | 2016-12-15 | |||
| WO2001000663A2 | 2001-01-04 |
Foreign References:
| JP2013502447A | 2013-01-24 | |||
| JP2010528011A | 2010-08-19 | |||
| JP2018125334A | 2018-08-09 |
Other References:
CELL, vol. 92, 1998, pages 573 - 585
CELL, vol. 98, 1999, pages 437 - 451
PROC. NATL. ACAD. SCI. USA, vol. 101, 2004, pages 4649 - 4654
NEURON, vol. 38, 2003, pages 715 - 730
CNS DRUGS, vol. 27, 2013, pages 83 - 90
CELL METABOLISM, vol. 9, 2009, pages 64 - 76
NEUROSCIENCE, vol. 121, 2003, pages 855 - 863
RESPIRATION, vol. 71, 2004, pages 575 - 579
PEPTIDES, vol. 23, 2002, pages 1683 - 1688
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, vol. 66, 2015, pages 2522 - 2533
BRAIN, vol. 130, 2007, pages 1586 - 1595
STRATEGIC APPLICATIONS OF NAMED REACTIONS IN ORGANIC SYNTHESIS, vol. 14-15
"Comprehensive Organic Transformations", 1989, VCH PUBLISHERS INC.
THEODORA W. GREENEPETER G. M. WUTS: "Protective Groups in Organic Synthesis", 2007, WILEY-INTERSCIENCE, INC.
P.J. KOCIENSKI: "Protecting Groups", 2004, THIEME
IYAKUHINKAIHATSU: "Design of Molecules", vol. 7, 1990, HIROKAWA SHOTEN, article "Development of Pharmaceuticals", pages: 163 - 198
BIOCHEM. J., vol. 340, no. 1, 1999, pages 283 - 289
See also references of EP 3816153A4
CELL, vol. 98, 1999, pages 437 - 451
PROC. NATL. ACAD. SCI. USA, vol. 101, 2004, pages 4649 - 4654
NEURON, vol. 38, 2003, pages 715 - 730
CNS DRUGS, vol. 27, 2013, pages 83 - 90
CELL METABOLISM, vol. 9, 2009, pages 64 - 76
NEUROSCIENCE, vol. 121, 2003, pages 855 - 863
RESPIRATION, vol. 71, 2004, pages 575 - 579
PEPTIDES, vol. 23, 2002, pages 1683 - 1688
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, vol. 66, 2015, pages 2522 - 2533
BRAIN, vol. 130, 2007, pages 1586 - 1595
STRATEGIC APPLICATIONS OF NAMED REACTIONS IN ORGANIC SYNTHESIS, vol. 14-15
"Comprehensive Organic Transformations", 1989, VCH PUBLISHERS INC.
THEODORA W. GREENEPETER G. M. WUTS: "Protective Groups in Organic Synthesis", 2007, WILEY-INTERSCIENCE, INC.
P.J. KOCIENSKI: "Protecting Groups", 2004, THIEME
IYAKUHINKAIHATSU: "Design of Molecules", vol. 7, 1990, HIROKAWA SHOTEN, article "Development of Pharmaceuticals", pages: 163 - 198
BIOCHEM. J., vol. 340, no. 1, 1999, pages 283 - 289
See also references of EP 3816153A4
Attorney, Agent or Firm:
TAKASHIMA, Hajime (JP)
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